@misc{oai:repo.qst.go.jp:00083572, author = {Go, Akamatsu and Eiji, Yoshida and Hideaki, Tashima and Shigeki, Ito and Yuma, Iwao and Hidekatsu, Wakizaka and Miwako, Takahashi and Taiga, Yamaya and Go, Akamatsu and Eiji, Yoshida and Hideaki, Tashima and Shigeki, Ito and Yuma, Iwao and Hidekatsu, Wakizaka and Miwako, Takahashi and Taiga, Yamaya}, month = {Oct}, note = {Once a high-resolution PET detector with both depth-of-interaction and time-of-flight capabilities is established, it will be applied to various-type PET systems using a software-based coincidence method. Toward this goal, we have developed a crosshair light-sharing (CLS) detector. In this work, as the first development of a practical system based on the CLS detector, we realized a high-resolution portable small animal PET with a long axial field-of-view (FOV) of 20 cm. The system was composed of 128 CLS detectors. All devices were mounted on a pushcart, and the system was operated on a 100V power supply. The axial FOV was 207 mm, which covered the total-body of a rat. A 22Na ultra-micro hot phantom was used for spatial resolution measurement, and the NEMA NU4 image quality phantom was used for image quality test. The developed CLS-PET system successfully resolved 0.75 mm rods. Subsequently, normal mouse and rat imaging with 18F-NaF and 18F-FDG were demonstrated. For the NaF-PET, mouse and rat total-body images were obtained, and detailed bone structures were clearly imaged. For the mouse FDG-PET, cardiac FDG uptakes were clearly visualized by the CLS-PET system. In conclusion, the CLS-PET system achieved <1 mm spatial resolution and successfully provided mouse and rat total-body images., 2021 IEEE NSS/MIC}, title = {CLS-PET: a high-resolution multi-purpose portable small-animal PET with DOI and TOF capability}, year = {2021} }