{"created":"2023-05-15T15:01:25.417163+00:00","id":83326,"links":{},"metadata":{"_buckets":{"deposit":"ad393894-6f18-4b07-a71c-dbb0150726a1"},"_deposit":{"created_by":1,"id":"83326","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83326"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083326","sets":["10:28"]},"author_link":["1000737","1000740","1000741","1000738","1000736","1000739"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-09-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"放射線は飛跡に沿って分子を電離することから，照射された細胞では，飛跡と重なるDNA部位に高密度な損傷（クラスター損傷）が生じると考えられている。しかし，実験的に高密度損傷の存在を実証した研究はなかった。そこで申請者はこれまでに、原子間力顕微鏡（AFM）を用いクラスター損傷を個別に可視化・検出方法を確立し、放射線を照射したプラスミドに生じた損傷の解析を行い、LETの増加によりクラスター損傷を伴う損傷が増加している事を明らかにし、これについて前年度の学会で報告した。その後さらに系を発展させ、AFMによるDNA損傷の可視化分析技術を発展的に展開し、放射線を照射した細胞や腫瘍中のDNAでも検討する方法を確立し、細胞や腫瘍中に生じた塩基損傷、クラスターダメージ、DSB末端に塩基損傷を含む新たなDNA損傷の観察を可能にした。本発表では、この系を軸に損傷毎の修復速度及び、修復欠損細胞で同様な検討を行い、クラスターダメージの修復機構を明らかにする。 ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"量子生命科学会第３回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中野, 敏彰"}],"nameIdentifiers":[{"nameIdentifier":"1000736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"赤松, 憲"}],"nameIdentifiers":[{"nameIdentifier":"1000737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鹿園, 直哉"}],"nameIdentifiers":[{"nameIdentifier":"1000738","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshiaki, Nakano","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000739","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ken, Akamatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000740","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naoya, Shikazono","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000741","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"AFMを用いた DNA損傷の可視化 ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AFMを用いた DNA損傷の可視化 "}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-13"},"publish_date":"2021-09-13","publish_status":"0","recid":"83326","relation_version_is_last":true,"title":["AFMを用いた DNA損傷の可視化 "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:40:17.081005+00:00"}