{"created":"2023-05-15T15:01:24.514273+00:00","id":83306,"links":{},"metadata":{"_buckets":{"deposit":"56e5a3cc-15f1-4ded-9146-d8abae7fb805"},"_deposit":{"created_by":1,"id":"83306","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83306"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083306","sets":["1"]},"author_link":["1000539","1000529","1000550","1000530","1000548","1000551","1000542","1000546","1000541","1000545","1000531","1000533","1000536","1000540","1000544","1000532","1000538","1000537","1000528","1000535","1000549","1000547","1000543","1000534"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"23","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"EJNMMI Radiopharmacy and Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\n[ 18 F]Fluoromisonidazole ([ 18 F]FMISO) and 1-[ 18 F]fluoro-3-((2-((1 E ,3 E )-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol ([18 F]PM-PBB3 or [ 18 F]APN-1607) are clinically used radiotracers for imaging hypoxia and tau pathology, respectively. Both radiotracers were produced by direct 18 F-fluorination using the corresponding tosylate precursors 1 or 2 and [ 18 F]F - , followed by the removal of protecting groups. In this study, we synthesized [ 18F]FMISO and [ 18 F]PM-PBB3 by 18 F-fluoroalkylation using [ 18 F]epifluorohydrin ([ 18 F] 5 ) for clinical applications.\nResults\nFirst, [ 18 F] 5 was synthesized by the reaction of 1,2-epoxypropyl tosylate ( 8 )\nwith [ 18 F]F - and was purified by distillation. Subsequently, [ 18 F] 5 was reacted with 2-nitroimidazole ( 6 ) or PBB3 ( 7 ) as a precursor for 18 F-labeling, and each reaction mixture was purified by preparative high-performance liquid chromatography and formulated to obtain the [ 18 F]FMISO or [ 18 F]PM-PBB3 injection. All synthetic sequences were performed using an automated 18 F-labeling synthesizer. The obtained [ 18 F]FMISO showed sufficient radioactivity (0.83 ± 0.20 GBq at the end of synthesis (EOS); n = 8) with appropriate radiochemical yield based on [ 18F]F - (26 ± 7.5% at EOS, decay-corrected; n = 8). The obtained [ 18 F]PM-PBB3 also showed sufficient radioactivity (0.79 ± 0.10 GBq at EOS; n = 11) with appropriate radiochemical yield based on [ 18 F]F - (16 ± 3.2% at EOS, decay-corrected; n = 11).\nConclusions\nBoth [ 18 F]FMISO and [ 18 F]PM-PBB3 injections were successfully synthesized with sufficient radioactivity by 18 F-fluoroalkylation using [ 18 F] 5 .","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SPRINGER NATURE"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s41181-021-00138-9","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://ejnmmipharmchem.springeropen.com/articles/10.1186/s41181-021-00138-9","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2365-421X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohkubo, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"1000528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Yusuke"}],"nameIdentifiers":[{"nameIdentifier":"1000529","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanao, Ogawa"}],"nameIdentifiers":[{"nameIdentifier":"1000530","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuki, Nengaki"}],"nameIdentifiers":[{"nameIdentifier":"1000531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Fujinaga"}],"nameIdentifiers":[{"nameIdentifier":"1000532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakana, Mori"}],"nameIdentifiers":[{"nameIdentifier":"1000533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsushi, Kumata"}],"nameIdentifiers":[{"nameIdentifier":"1000534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu"}],"nameIdentifiers":[{"nameIdentifier":"1000535","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenji, Furutsuka"}],"nameIdentifiers":[{"nameIdentifier":"1000536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroki, Hashimoto"}],"nameIdentifiers":[{"nameIdentifier":"1000537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Kawamura"}],"nameIdentifiers":[{"nameIdentifier":"1000538","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1000539","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanao, Ogawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuki, Nengaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Fujinaga","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakana, Mori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsushi, Kumata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenji, Furutsuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroki, Hashimoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Kawamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000551","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-10"},"publish_date":"2021-06-10","publish_status":"0","recid":"83306","relation_version_is_last":true,"title":["Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:41:08.859713+00:00"}