{"created":"2023-05-15T15:01:23.749617+00:00","id":83289,"links":{},"metadata":{"_buckets":{"deposit":"1d10ac9b-a1d0-4631-8aa1-f23c4d3399a1"},"_deposit":{"created_by":1,"id":"83289","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83289"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083289","sets":["10:29"]},"author_link":["999178","999181","999180","999179","999177","999175","999174","999176"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-09-11","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[目的]がんの初期治療によって誘発される組織修復過程では、テネイシンC (TNC)が誘導される。誘導されたTNCを標的とすることで、修復反応が起こっている場所に、薬剤を集中的に運搬できるかどうかを検証した。[方法]In-111標識抗TNC抗体3種類及びcontrol抗体を、放射線照射(30Gy)または非照射担がんマウスに投与し、体内動態、SPECT/CT、ARGを実施した。[結果]体内動態試験で、抗TNC抗体3-6でのみ、照射された腫瘍への取込が投与1日後に2倍上昇することが観察された。SPECT/CTでも腫瘍集積の有意な上昇が確認された。ARGより、非照射腫瘍では腫瘍集積が限局的だったが、照射腫瘍では腫瘍内全体に高い集積を認めた。control抗体では照射群でも低いシグナルが観察されたのみであった。[結論]抗TNC抗体3-6を利用することで、初期治療を受けた後に修復反応が起こっている場所に、RIを含む薬剤を2倍以上運搬できることが明らかとなった。今後、治療効果を検証していく予定である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第16回小動物インビボイメージング研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"999174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭, 綾"}],"nameIdentifiers":[{"nameIdentifier":"999175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤, 仁美"}],"nameIdentifiers":[{"nameIdentifier":"999176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東, 達也"}],"nameIdentifiers":[{"nameIdentifier":"999177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsushi, Tsuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aya, Sugyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitomi, Sudo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuya, Higashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999181","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"組織修復時に誘発されるテネイシンCを標的とした治療法の可能性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"組織修復時に誘発されるテネイシンCを標的とした治療法の可能性"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-08-19"},"publish_date":"2021-08-19","publish_status":"0","recid":"83289","relation_version_is_last":true,"title":["組織修復時に誘発されるテネイシンCを標的とした治療法の可能性"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:46:12.238303+00:00"}