{"created":"2023-05-15T15:01:18.465916+00:00","id":83171,"links":{},"metadata":{"_buckets":{"deposit":"3e9568ae-fc8a-4d37-977e-d9f0b482c5c8"},"_deposit":{"created_by":1,"id":"83171","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83171"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083171","sets":["10:29"]},"author_link":["996479","996495","996498","996477","996503","996485","996490","996491","996501","996480","996475","996476","996488","996500","996504","996481","996497","996486","996487","996483","996493","996496","996482","996484","996492","996499","996489","996494","996502","996478"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-07-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景】22q11.2欠失症候群(22q11DS)は、第22染色体の長腕11.2領域欠失により生じ、先天性心疾患、パーキンソン病、統合失調症、強迫性障害、知的障害など幅広い臨床症状を有する遺伝的症候群である。22q11DSでは、特に線条体外において、シナプス間隙のドーパミン（DA）濃度を調節する酵素であるcatechol-O-methyl-transferase（COMT）遺伝子のハプロ不全をもたらすことから、22q11DSではDA神経伝達異常が起こっている可能性がある。本研究では、22q11DSにおける脳内ドーパミン神経伝達の変化を明らかにすることを目的とし、成人22q11DS患者および健常者を対象に、PETにより線条体外におけるドーパミンD1およびD2受容体密度を調べた。\n【方法】22q11DS 5名(平均36.3歳)、および同年代の健常被験者10名(平均35.8歳)に対して11C-SCH23390を用いたD1受容体PET、11C-FLB457を用いたD2受容体PET検査を実施した。11C-SCH23390および11C-FLB457 PETでは、小脳を参照領域としたsimplified reference tissue model法により各々D1およびD2受容体密度の指標 (BPND) を求めた。\n【結果】患者群では健常群に比較して、側頭葉における11C-SCH23390 PETによるBPNDの有意な上昇を認めたが (analysis of covariance, F = 6.34, p = 0.027)、そのほかの領域ではBPNDに有意な群間差を認めなかった。また、患者群において、11C-FLB457 PETによるBPNDでも上昇傾向を側頭葉において認めたが有意ではなく(analysis of covariance, F = 2.46, p = 0.145)、そのほかの領域ではBPNDに有意な群間差を認めなかった。また、両群とも、全領域にて11C-SCH23390 BPNDと、11C-FLB457 BPNDは、加齢に伴い低下する傾向を認めた。\n【考察】本研究により、22q11DSでは側頭葉におけるD1およびD2受容体密度が上昇している可能性が示され、ドーパミン神経伝達機構の制御が障害されている可能性が示唆された。少数例の検討であるため、今後はさらに症例数を増やす必要がある。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第43回日本生物学的精神医学会・第51回日本神経精神薬理学会　合同年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 保天"}],"nameIdentifiers":[{"nameIdentifier":"996475","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑, 圭輔"}],"nameIdentifiers":[{"nameIdentifier":"996476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保田, 学"}],"nameIdentifiers":[{"nameIdentifier":"996477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐野, 康徳"}],"nameIdentifiers":[{"nameIdentifier":"996478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高堂, 裕平"}],"nameIdentifiers":[{"nameIdentifier":"996479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松岡, 究"}],"nameIdentifiers":[{"nameIdentifier":"996480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤, 浩信"}],"nameIdentifiers":[{"nameIdentifier":"996481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森口, 翔"}],"nameIdentifiers":[{"nameIdentifier":"996482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"996483","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"互, 健二"}],"nameIdentifiers":[{"nameIdentifier":"996484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"996485","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"996486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三村, 將"}],"nameIdentifiers":[{"nameIdentifier":"996487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"996488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"996489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Yasuharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996490","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Keisuke, Takahata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Manabu, Kubota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasunori, Sano","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuhei, Takado","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996494","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiwamu, Matsuoka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hironobu, Endo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sho, Moriguchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chie, Seki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenji, Tagai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Kawamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masaru, Mimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Suhara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996504","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"22q11.2欠失症候群における線条体外ドーパミンD1およびD2受容体密度に関する検討：11C-SCH23390と11C-FLB457を用いたPET研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"22q11.2欠失症候群における線条体外ドーパミンD1およびD2受容体密度に関する検討：11C-SCH23390と11C-FLB457を用いたPET研究"},{"subitem_title":"Increased extra-striatal dopamine D1 and D2 receptor availability in 22q11.2 deletion syndrome reveled by PET","subitem_title_language":"en"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-08-03"},"publish_date":"2021-08-03","publish_status":"0","recid":"83171","relation_version_is_last":true,"title":["22q11.2欠失症候群における線条体外ドーパミンD1およびD2受容体密度に関する検討：11C-SCH23390と11C-FLB457を用いたPET研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:56:52.758654+00:00"}