{"created":"2023-05-15T15:01:17.436430+00:00","id":83148,"links":{},"metadata":{"_buckets":{"deposit":"76a0bf59-9711-48ca-988e-2c1cb6cb1422"},"_deposit":{"created_by":1,"id":"83148","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83148"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083148","sets":["10:29"]},"author_link":["996004","996023","995999","996019","996009","996008","996021","996011","996016","996006","996020","996026","996002","996000","996015","996007","996005","996017","995998","996027","995997","996001","996022","995995","996014","995996","996024","996003","996013","996018","996012","996025","996010","995994"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-07-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景】慢性外傷性脳症(chronic traumatic encephalopathy: CTE)は、反復性軽度頭部外傷によって引き起こされるタウオパチーである。タウPETの開発により頭部外傷による脳内タウ病変を生存中に可視化することが可能となったが、第1世代タウPET薬では単一症例レベルの高精度な診断を行うことは困難であった。量研機構は、第２世代タウPET薬である18F-PM-PBB3を開発し、多様なタウオパチーを高精度に評価することに成功した。本研究では、ボクサーを対象に18F-PM-PBB3を用いたPETを行い、タウ病変の分布を検討するとともに、脳局所におけるタウ蓄積量と外傷歴や精神神経症状との関連を検討した。【方法】元ボクサー 18名(ボクシング従事年数 15.4年)、および同年代の健常被験者に対して18F-PM-PBB3を用いたタウPET、11C-PiB によりアミロイドPET、MRIおよび神経心理検査を実施した。脳内タウ蓄積量は、小脳を参照領域とするSUVR(standard uptake tissue ratio)法にて定量した。18F-PM-PBB3の集積分布に関しては、２名以上の医師によって定性的評価を行なった。【結果】ボクサー群は、健常群に比較して、大脳皮質、白質、皮質-白質境界部において18F-PM-PBB3のSUVR値が有意に高く (P = 0.0002)、タウ蓄積量の増加が示唆された。ボクサーにおける18F-PM-PBB3集積分布は、(A)脳内に有意な集積を認めないタイプ(4名)、(B)脳の局所にびまん性の集積を認めるタイプ(5名)、(C)皮質-白質境界部の脳溝深部に多発散在性の集積を認めるタイプ(8名)の3つの類型に分類された。特に(C)はCTE/ボクサー脳症の死後脳所見に非常に類似していた。また、(A)-(C)の集積パターンと、精神神経症状には一定の関係性が認められた。11C-PiBによるアミロイドPETは全例で陰性であった。【考察】18F-PM-PBB3によるPETにより、ボクシングによって引き起こされる脳内タウ蓄積には複数の類型が存在し、それぞれ異なる精神神経症状を呈する傾向が示された。本結果は、頭部外傷による遅発性脳障害の発現機序を解明するための重要な知見と考えられる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第43回日本生物学的精神医学会・第51回日本神経精神薬理学会　合同年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高畑, 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18F-PM-PBB3(18F-APN-1607)","subitem_title_language":"en"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-07-20"},"publish_date":"2021-07-20","publish_status":"0","recid":"83148","relation_version_is_last":true,"title":["慢性外傷性脳症(ボクサー脳症)における脳内タウ蓄積と精神神経症状との関連に関する検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:58:50.860315+00:00"}