{"created":"2023-05-15T15:01:13.707029+00:00","id":83063,"links":{},"metadata":{"_buckets":{"deposit":"e0343d4d-c199-43fb-ade3-32e75929471c"},"_deposit":{"created_by":1,"id":"83063","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83063"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083063","sets":["1"]},"author_link":["1016031","1016037","1016034","1016041","1016040","1016033","1016029","1016036","1016032","1016039","1016030","1016038","1016035"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"e3001055","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"PLoS biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It has been widely accepted that dopamine (DA) plays a major role in motivation, yet the specific contribution of DA signaling at D1-like receptor (D1R) and D2-like receptor (D2R) to cost-benefit trade-off remains unclear. Here, by combining pharmacological manipulation of DA receptors (DARs) and positron emission tomography (PET) imaging, we assessed the relationship between the degree of D1R/D2R blockade and changes in benefit- and cost-based motivation for goal-directed behavior of macaque monkeys. We found that the degree of blockade of either D1R or D2R was associated with a reduction of the positive impact of reward amount and increasing delay discounting. Workload discounting was selectively increased by D2R antagonism. In addition, blocking both D1R and D2R had a synergistic effect on delay discounting but an antagonist effect on workload discounting. These results provide fundamental insight into the distinct mechanisms of DA action in the regulation of the benefit- and cost-based motivation, which have important implications for motivational alterations in both neurological and psychiatric disorders.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34197448","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pbio.3001055","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001055","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1544-9173","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hori, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"1016029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagai, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"1016030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mimura, Koki"}],"nameIdentifiers":[{"nameIdentifier":"1016031","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"1016032","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"1016033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bouret, Sebastien"}],"nameIdentifiers":[{"nameIdentifier":"1016034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamimoto, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"1016035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yukiko, Hori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuji, Nagai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koki, Mimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Suhara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016039","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takafumi, Minamimoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016041","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost–benefit evaluation and motivation in monkeys","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost–benefit evaluation and motivation in monkeys"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-07-02"},"publish_date":"2021-07-02","publish_status":"0","recid":"83063","relation_version_is_last":true,"title":["D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost–benefit evaluation and motivation in monkeys"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:41:40.987883+00:00"}