@article{oai:repo.qst.go.jp:00083063,
 author = {Hori, Yukiko and Nagai, Yuji and Mimura, Koki and Suhara, Tetsuya and Higuchi, Makoto and Bouret, Sebastien and Minamimoto, Takafumi and Yukiko, Hori and Yuji, Nagai and Koki, Mimura and Tetsuya, Suhara and Makoto, Higuchi and Takafumi, Minamimoto},
 issue = {7},
 journal = {PLoS biology},
 month = {Jan},
 note = {It has been widely accepted that dopamine (DA) plays a major role in motivation, yet the specific contribution of DA signaling at D1-like receptor (D1R) and D2-like receptor (D2R) to cost-benefit trade-off remains unclear. Here, by combining pharmacological manipulation of DA receptors (DARs) and positron emission tomography (PET) imaging, we assessed the relationship between the degree of D1R/D2R blockade and changes in benefit- and cost-based motivation for goal-directed behavior of macaque monkeys. We found that the degree of blockade of either D1R or D2R was associated with a reduction of the positive impact of reward amount and increasing delay discounting. Workload discounting was selectively increased by D2R antagonism. In addition, blocking both D1R and D2R had a synergistic effect on delay discounting but an antagonist effect on workload discounting. These results provide fundamental insight into the distinct mechanisms of DA action in the regulation of the benefit- and cost-based motivation, which have important implications for motivational alterations in both neurological and psychiatric disorders.},
 title = {D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost–benefit evaluation and motivation in monkeys},
 volume = {19},
 year = {2022}
}