@article{oai:repo.qst.go.jp:00082989,
 author = {Suga, Makito and Nishii, Ryuichi and Miwa, kenta and Kamitaka, Yuto and Yamazaki, Kana and Tamura, Kentaro and Yamamoto, Naoyoshi and Kohno, Ryosuke and Kobayashi, Masato and Tanimoto, Katsuyuki and Tsuji, Hiroshi and Higashi, Tatsuya and Ryuichi, Nishii and Yuto, Kamitaka and Kana, Yamazaki and Kentaro, Tamura and Naoyoshi, Yamamoto and Ryosuke, Kohno and Katsuyuki, Tanimoto and Hiroshi, Tsuji and Tatsuya, Higashi},
 issue = {1},
 journal = {Scientific reports},
 month = {Jun},
 note = {The differentiation of non-small cell lung cancer (NSCLC) and radiation pneumonitis (RP) is critically essential for selecting optimal clinical therapeutic strategies to manage post carbon-ion radiotherapy (CIRT) in patients with NSCLC. The aim of this study was to assess the ability of F-FDG PET/CT metabolic parameters and its textural image features to differentiate NSCLC from RP after CIRT to develop a differential diagnosis of malignancy and benign lesion. We retrospectively analyzed F-FDG PET/CT image data from 32 patients with histopathologically proven NSCLC who were scheduled to undergo CIRT and 31 patients diagnosed with RP after CIRT. The SUV parameters, metabolic tumor volume (MTV), total lesion glycolysis (TLG) as well as fifty-six texture parameters derived from seven matrices were determined using PETSTAT image-analysis software. Data were statistically compared between NSCLC and RP using Wilcoxon rank-sum tests. Diagnostic accuracy was assessed using receiver operating characteristics (ROC) curves. Several texture parameters significantly differed between NSCLC and RP (p < 0.05). The parameters that were high in areas under the ROC curves (AUC) were as follows: SUV, 0.64; GLRLM run percentage, 0.83 and NGTDM coarseness, 0.82. Diagnostic accuracy was improved using GLRLM run percentage or NGTDM coarseness compared with SUV (p < 0.01). The texture parameters of F-FDG uptake yielded excellent outcomes for differentiating NSCLC from radiation pneumonitis after CIRT, which outperformed SUV-based evaluation. In particular, GLRLM run percentage and NGTDM coarseness of F-FDG PET/CT images would be appropriate parameters that can offer high diagnostic accuracy.},
 title = {Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis},
 volume = {11},
 year = {2021}
}