{"created":"2023-05-15T15:01:08.388280+00:00","id":82943,"links":{},"metadata":{"_buckets":{"deposit":"4a8fd90b-93b7-4a49-8e6c-6d25b0f3179d"},"_deposit":{"created_by":1,"id":"82943","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"82943"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00082943","sets":["1"]},"author_link":["997033","997032","997035","997031","997029","997034","997030","997028"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"833","bibliographicPageStart":"823","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Annals of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To examine the impact of acquisition time on Lutetium-177 (177Lu) single-photon emission computed tomography (SPECT) images using Monte Carlo simulation.\n\nMethods: A gamma camera simulation based on the Monte Carlo method was performed to produce SPECT images. The phantom was modeled on a NEMA IEC BODY phantom including six spheres as tumors. After the administration of 7.4 GBq of 177Lu, radioactivity concentrations of the tumor/liver at 6, 24, and 72 h after administration were set to 1.85/0.201, 2.12/0.156, and 1.95/0.117 MBq/mL, respectively. In addition, the radioactivity concentrations of the tumor at 72 h after administration varied by 1/2, 1/4, and 1/8 when comparison was made. Acquisition times examined were 1.2, 1.5, 2, 3, 6, and 12 min. To assess the impact of collimators, SPECT data acquired at 72 h after the administration using six collimators of low-energy high-resolution (LEHR), extended low-energy general-purpose (ELEGP), medium-energy, and general-purpose (MEGP-1, MEGP-2, and MEGP-3) and high-energy general-purpose (HEGP) were examined. After prefiltering using a Butterworth filter, projection images were reconstructed using ordered subset expectation maximization. The detected photons were classified into direct rays, scattered rays, penetrating rays, and characteristic X-rays from lead. The image quality was evaluated through visual assessment, and physical assessment of contrast recovery coefficient (CRC) and contrast-to-noise ratio (CNR). In this study, the CNR threshold for detectability was assumed to be 5.0.\n\nResults: To compare collimators, the highest sensitivity was observed with ELEGP, followed by LEHR and MEGP-1. The highest ratio of direct ray was also observed in ELEGP followed by MEGP-1. In comparison of the radioactivity concentration ratios of tumor/liver, CRC and CNR were significantly decreased with smaller radioactivity concentration ratios. This effect was greater with larger spheres. According to the visual assessment, the acquisition time of 6, 6, and 3 min or longer was required using ELEGP collimator at 6, 24, and 72 h after administration, respectively. Physical assessment based on CNR and CRC also suggested that 6, 6, and 3 min or longer acquisition time was necessary at 6, 24, and 72 h after administration.\n\nConclusion: 177Lu-SPECT images generated via the Monte Carlo simulation suggested that the recommended acquisition time was 6 min or longer at 6 and 24 h and 3 min or longer at 72 h after administration.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34057655","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12149-021-01620-9","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://link.springer.com/article/10.1007%2Fs12149-021-01620-9","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-7187","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yuya, Sekikawa"}],"nameIdentifiers":[{"nameIdentifier":"997028","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Keita, Funada"}],"nameIdentifiers":[{"nameIdentifier":"997029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Go, Akamatsu"}],"nameIdentifiers":[{"nameIdentifier":"997030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazuhiko, Himuro"}],"nameIdentifiers":[{"nameIdentifier":"997031","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akihiko, Takahashi"}],"nameIdentifiers":[{"nameIdentifier":"997032","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shingo, Baba"}],"nameIdentifiers":[{"nameIdentifier":"997033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Sasaki"}],"nameIdentifiers":[{"nameIdentifier":"997034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Go, Akamatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"997035","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Monte Carlo simulation of the acquisition conditions for 177Lu molecular imaging of hepatic tumors.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Monte Carlo simulation of the acquisition conditions for 177Lu molecular imaging of hepatic tumors."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-04"},"publish_date":"2021-06-04","publish_status":"0","recid":"82943","relation_version_is_last":true,"title":["Monte Carlo simulation of the acquisition conditions for 177Lu molecular imaging of hepatic tumors."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:55:09.503080+00:00"}