{"created":"2023-05-15T15:01:03.314633+00:00","id":82825,"links":{},"metadata":{"_buckets":{"deposit":"a928b59b-da41-430d-bd6b-62fbb490c993"},"_deposit":{"created_by":1,"id":"82825","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"82825"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00082825","sets":["1"]},"author_link":["1017098","1017101","1017109","1017112","1017104","1017096","1017095","1017099","1017103","1017106","1017111","1017094","1017107","1017102","1017108","1017105","1017097","1017110","1017100"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"2581","bibliographicPageStart":"2571","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Previous work found that [C]deschloroclozapine ([C]DCZ) is superior to [C]clozapine ([C]CLZ) for imaging Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). This study used PET to quantitatively and separately measure the signal from transfected receptors, endogenous receptors/targets, and non-displaceable binding in other brain regions to better understand this superiority. A genetically-modified muscarinic type-4 human receptor (hMDi) was injected into the right amygdala of a male rhesus macaque. [C]DCZ and [C]CLZ PET scans were conducted 2-24 months later. Uptake was quantified relative to the concentration of parent radioligand in arterial plasma at baseline (n = 3 scans/radioligand) and after receptor blockade (n = 3 scans/radioligand). Both radioligands had greater uptake in the transfected region and displaceable uptake in other brain regions. Displaceable uptake was not uniformly distributed, perhaps representing off-target binding to endogenous receptor(s). After correction, [C]DCZ signal was 19% of that for [C]CLZ, and background uptake was 10% of that for [C]CLZ. Despite stronger [C]CLZ binding, the signal-to-background ratio for [C]DCZ was almost two-fold greater than for [C]CLZ. Both radioligands had comparable DREADD selectivity. All reference tissue models underestimated signal-to-background ratio in the transfected region by 40%-50% for both radioligands. Thus, the greater signal-to-background ratio of [C]DCZ was due to its lower background uptake.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SAGE Publications"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33853405","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1177/0271678X211007949","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://journals.sagepub.com/doi/full/10.1177/0271678X211007949","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0271-678X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yan, Xuefeng"}],"nameIdentifiers":[{"nameIdentifier":"1017094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Telu, Sanjay"}],"nameIdentifiers":[{"nameIdentifier":"1017095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"M Dick, Rachel"}],"nameIdentifiers":[{"nameIdentifier":"1017096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jeih-San, Liow"}],"nameIdentifiers":[{"nameIdentifier":"1017097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Paolo, Zanotti-Fregonara"}],"nameIdentifiers":[{"nameIdentifier":"1017098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"L Morse, Cheryl"}],"nameIdentifiers":[{"nameIdentifier":"1017099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"S Manly, Lester"}],"nameIdentifiers":[{"nameIdentifier":"1017100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"L Gladding, Robert"}],"nameIdentifiers":[{"nameIdentifier":"1017101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shrestha, Stal"}],"nameIdentifiers":[{"nameIdentifier":"1017102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lerchner, Walter"}],"nameIdentifiers":[{"nameIdentifier":"1017103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagai, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"1017104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamimoto, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"1017105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"S Zoghbi, Sami"}],"nameIdentifiers":[{"nameIdentifier":"1017106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"B Innis, Robert"}],"nameIdentifiers":[{"nameIdentifier":"1017107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"W Pike, Victor"}],"nameIdentifiers":[{"nameIdentifier":"1017108","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"J Richmond, Barry"}],"nameIdentifiers":[{"nameIdentifier":"1017109","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ag Eldridge, Mark"}],"nameIdentifiers":[{"nameIdentifier":"1017110","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuji, Nagai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1017111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takafumi, Minamimoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1017112","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-13"},"publish_date":"2021-05-13","publish_status":"0","recid":"82825","relation_version_is_last":true,"title":["[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:36:06.347961+00:00"}