{"created":"2023-05-15T15:00:56.682295+00:00","id":82670,"links":{},"metadata":{"_buckets":{"deposit":"9d478bf3-db2f-4b53-80b7-5e2196b74e52"},"_deposit":{"created_by":1,"id":"82670","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"82670"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00082670","sets":["1"]},"author_link":["1013394","1013392","1013390","1013389","1013396","1013379","1013385","1013391","1013380","1013384","1013386","1013393","1013397","1013378","1013383","1013381","1013388","1013382","1013395","1013387"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"1019","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Cells"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Malignant pleural mesothelioma (MPM) has extremely limited treatment despite a poor prognosis. Moreover, molecular targeted therapy for MPM has not yet been implemented; thus, a new targeted therapy is highly desirable. Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed cancer therapy that combines the specificity of antibodies for targeting tumors with toxicity induced by the photoabsorber after exposure to NIR-light. In this study, we developed a new phototherapy targeting podoplanin (PDPN) for MPM with the use of both NIR-PIT and an anti-PDPN antibody, NZ-1. An antibody-photosensitizer conjugate consisting of NZ-1 and phthalocyanine dye was synthesized. In vitro NIR-PIT-induced cytotoxicity was measured with both dead cell staining and luciferase activity on various MPM cell lines. In vivo NIR-PIT was examined in both the flank tumor and orthotopic mouse model with in vivo real-time imaging. In vitro NIR-PIT-induced cytotoxicity was NIR-light dose dependent. In vivo NIR-PIT led to significant reduction in both tumor volume and luciferase activity in a flank model (p < 0.05, NIR-PIT group versus NZ-1-IR700 group). The PDPN-targeted NIR-PIT resulted in a significant antitumor effect in an MPM orthotopic mouse model (p < 0.05, NIR-PIT group versus NZ-1-IR700 group). This study suggests that PDPN-targeted NIR-PIT could be a new promising treatment for MPM.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/cells9041019","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/32326079/","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2073-4409","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishinaga, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"1013378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Kazuhide"}],"nameIdentifiers":[{"nameIdentifier":"1013379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasui, Hirotoshi"}],"nameIdentifiers":[{"nameIdentifier":"1013380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taki, Shunichi"}],"nameIdentifiers":[{"nameIdentifier":"1013381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Kazuomi"}],"nameIdentifiers":[{"nameIdentifier":"1013382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Misae"}],"nameIdentifiers":[{"nameIdentifier":"1013383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Rena"}],"nameIdentifiers":[{"nameIdentifier":"1013384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koike, Chiaki"}],"nameIdentifiers":[{"nameIdentifier":"1013385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuramoto, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"1013386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Shota"}],"nameIdentifiers":[{"nameIdentifier":"1013387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukui, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"1013388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Yukawa"}],"nameIdentifiers":[{"nameIdentifier":"1013389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshinobu, Baba"}],"nameIdentifiers":[{"nameIdentifier":"1013390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"K Kaneko, Mika"}],"nameIdentifiers":[{"nameIdentifier":"1013391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toyofumi, F Chen-Yoshikawa"}],"nameIdentifiers":[{"nameIdentifier":"1013392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Hisataka"}],"nameIdentifiers":[{"nameIdentifier":"1013393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Yukinari"}],"nameIdentifiers":[{"nameIdentifier":"1013394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Yoshinori"}],"nameIdentifiers":[{"nameIdentifier":"1013395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Yukawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1013396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshinobu, Baba","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1013397","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Targeted phototherapy for malignant pleural mesothelioma: near-infrared photoimmunotherapy targeting podoplanin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Targeted phototherapy for malignant pleural mesothelioma: near-infrared photoimmunotherapy targeting podoplanin"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-08"},"publish_date":"2021-04-08","publish_status":"0","recid":"82670","relation_version_is_last":true,"title":["Targeted phototherapy for malignant pleural mesothelioma: near-infrared photoimmunotherapy targeting podoplanin"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:52:46.400114+00:00"}