@article{oai:repo.qst.go.jp:00082622, author = {Shigeki, Watanabe and Masashi, Koka (Beam Operation) and Enomoto, Kazuyuki and Nobumasa, Miyawaki and Tetsuya, Sakashita and Ichiro, Sasaki and Noriko, Ishioka and Shigeki, Watanabe and Enomoto, Kazuyuki and Nobumasa, Miyawaki and Tetsuya, Sakashita and Ichiro, Sasaki and Noriko, Ishioka}, journal = {QST Takasaki Annual Report 2019}, month = {Mar}, note = {Astatine-211 is one of the promising alpha-emitting radionuclides for the targeted alpha therapy (TAT), internal radiotherapy using alpha-emitting radioisotopes. At-211 is basically produced by irradiating He beams with 28–29 MeV to a bismuth (Bi) target. Irradiations with high beam current (µA order) are necessary to produce At-211 for preclinical and clinical studies because they require its radioactivity on the order of subGBq to GBq. Low melting point of Bi (273.1°C) often causes melting of the Bi during irradiation with high beam current. The aim of this study is therefore to optimize irradiation condition without observing Bi melting.}, title = {Evaluation of the Cooling Effect by He Gas for the Production of At-211 with a Bi plate}, year = {2021} }