{"created":"2023-05-15T15:00:51.367633+00:00","id":82553,"links":{},"metadata":{"_buckets":{"deposit":"83ba83a8-7005-4d87-b026-aaef067a4ae8"},"_deposit":{"created_by":1,"id":"82553","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"82553"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00082553","sets":["1"]},"author_link":["1014334","1014322","1014331","1014330","1014337","1014328","1014332","1014339","1014338","1014326","1014335","1014341","1014340","1014342","1014324","1014329","1014323","1014343","1014336","1014327","1014325","1014333"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"2422","bibliographicPageStart":"2410","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Journal of cerebral blood flow and metabolism "}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. In this study, we developed a novel PET radioligand for CSF1R, C-GW2580, and compared it to a reported CSF1R tracer, C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey. Dynamic C-GW2580- and C-CPPC-PET images were quantified by reference tissue-based models and standardized uptake value ratio. Both tracers exhibited increased uptake in the lesioned striata of lipopolysaccharide-injected mice and in the forebrains of -knock-in mice, spatially in agreement with an increased 18-kDa translocator protein radioligand retention. Moreover, C-GW2580 captured changes in CSF1R availability more sensitively than C-CPPC, with a larger dynamic range and a smaller inter-individual variability, in these model animals. PET imaging of CSF1R in a rhesus monkey displayed moderate-to-high tracer retention in the brain at baseline. Homologous blocker (i. e. unlabeled tracer) treatment reduced the uptake of C-GW2580 by ∼30% in all examined brain regions except for centrum semi-ovale white matter, but did not affect the retention of C-CPPC. In summary, our results demonstrated that C-GW2580-PET captured inflammatory microgliosis in the mouse brain with higher sensitivity than a reported radioligand, and displayed saturable binding in the monkey brain, potentially providing an imaging-based quantitative biomarker for reactive microgliosis.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SAGE Publications"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33757319","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1177/0271678X211004146","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://journals.sagepub.com/doi/10.1177/0271678X211004146","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0271-678X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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Zhang"}],"nameIdentifiers":[{"nameIdentifier":"1014328","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"1014329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"C Saido, Takaomi"}],"nameIdentifiers":[{"nameIdentifier":"1014330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"1014331","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"1014332","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"1014333","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xiaoyun, Zhou","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014334","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ji, Bin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chie, Seki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuji, Nagai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takafumi, Minamimoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Fujinaga","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Suhara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuyuki, Kimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014343","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-30"},"publish_date":"2021-03-30","publish_status":"0","recid":"82553","relation_version_is_last":true,"title":["PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:48:53.530084+00:00"}