@article{oai:repo.qst.go.jp:00082366,
 author = {Hiroki Kawaguchi and Demizu, Yusuke and Naritoshi, Mukumoto and Ishihara, Takeaki and Daisuke, Miyawaki and Komatsu , Shohei and Hiroaki, Akasaka and Makoto, Shinoto and Yoshiyuki, Shioyama and Katsumasa, Nakamura and Fukumoto, Takumi and Ryohei, Sasaki and Naritoshi, Mukumoto and Daisuke, Miyawaki and Hiroaki, Akasaka and Makoto, Shinoto and Yoshiyuki, Shioyama and Katsumasa, Nakamura and Ryohei, Sasaki},
 issue = {1},
 journal = {Anticancer research},
 month = {Jan},
 note = {Background/aim: We aimed to investigate the dosimetric effects of a spacer placed between the pancreas and surrounding gastrointestinal structures in intensity-modulated radiation therapy (IMRT) planning to provide more effective radiation therapy for locally advanced pancreatic cancer (LAPC). 

Patients and methods: Treatment planning was performed for six patients with LAPC based on computed tomography images without spacers and with 5-mm or 10-mm spacers virtually inserted under the supervision of a hepatobiliary pancreatic surgeon. The prescription dose was 63 Gy in 28 fractions. 

Results: With the exception of one case of pancreatic head cancer, planning target volume receiving ≥95% of the prescribed dose (PTV V95) was achieved by 90% or more by inserting a spacer, and by 95% or more in all 3 cases of pancreatic body and tail cancer by inserting a 10-mm spacer. 

Conclusion: IMRT with appropriate spacer placement may help provide high-dose treatment for LAPC and improve associated patient outcomes.},
 pages = {503--508},
 title = {Efficacy of Spacers in Radiation Therapy for Locally Advanced Pancreatic Cancer: A Planning Study},
 volume = {41},
 year = {2021}
}