@misc{oai:repo.qst.go.jp:00082352,
 author = {Sakamoto, Ayako and Sakamoto, Tomoaki and Yokota, Yuuichiro and Teranishi , Mika and kimura, Seisuke and Ayako, Sakamoto and Yuuichiro, Yokota},
 month = {Mar},
 note = {A NAC-type transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1), found in seed plants, is a master regulator for DNA damage responses (DDR). Upon DNA damage, SOG1 is phosphorylated by the ATM, a conserved Ser/Thr kinase in both animal and plant kingdoms. Then it regulates the expression of a large number of downstream DDR genes. To know the origin of DDR network in land plants, we searched for a homologue(s) of SOG1 in a moss Physcomitrella patens and identified PpSOG1a and PpSOG1b. To assess if either of them, or both, function(s) in DDR, we established knockout plant lines via CRISPR/Cas9 gene editing. Although neither sog1a nor sog1b single mutant showed obviously notable phenotypes, the double knockout sog1a sog1b plants showed reduced expression of DNA-repair genes after gamma-irradiation. The double mutant also showed resistance to several DNA-damaging treatments as similarly seen in Arabidopsis sog1 plants. These results suggest that PpSOG1a and PpSOG1b work redundantly on DDR response in P. patens, and also that the plant specific DDR system had been established prior to the emerging of vascular plants., 第62回日本植物生理学会年会},
 title = {SOG1 homologues regulate DNA-damage responses in Physcomitrella patens.},
 year = {2021}
}