{"created":"2023-05-15T15:00:18.290084+00:00","id":81842,"links":{},"metadata":{"_buckets":{"deposit":"4638f8d8-cc4f-4414-80a9-f23f7b301279"},"_deposit":{"created_by":1,"id":"81842","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81842"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081842","sets":["1"]},"author_link":["1012383","1012387","1012403","1012400","1012389","1012399","1012396","1012391","1012398","1012392","1012386","1012385","1012390","1012402","1012393","1012405","1012404","1012388","1012384","1012397","1012394","1012395","1012382","1012401"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"222","bibliographicPageStart":"211","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Annals of nuclear medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: The aim of this study was to assess the clinical value of [11C]4DST uptake in patients with lung nodules, including benign and malignant tumors, and to assess the correlation between [11C]4DST uptake and proliferative activity of tumors in comparison with [18F]FDG uptake.\nMethods: Twenty-six patients (22 males and 4 females, mean age of 65.5-year-old) were analyzed in this prospective study. Patients underwent [11C]4DST and [18F]FDG PET/CT imaging on the same day. Diagnosis of each lung nodule was confirmed by histopathological examination of tissue specimens at surgery, or during clinical follow-up after the PET/CT studies. To assess the utility of the semi-quantitative evaluation method, the SUVmax was calculated of [11C]4DST and [18F]FDG uptake by the lesion. Proliferative activities of each tumor as indicated by the immunohistochemical Ki-67 index was also estimated using surgical specimens of patients. Then the relationship between the SUVmax of both PET/CT and the Ki-67 index was examined. Furthermore, the relationship between the uptake of [11C]4DST or [18F]FDG and the histopathological findings, the clinical stage, and the clinical outcome of patients were also assessed.\nResults: There was a positive linear relationship between the SUVmax of [11C]4DST images and the Ki-67 index (Correlation coefficients = 0.68). The SUVmax of [11C]4DST in the 26 lung nodules were 1.65 ± 0.40 for benign lesions, 3.09 ± 0.83 for adenocarcinomas (P < 0.001 between benign and adenocarcinoma), and 2.92 ± 0.58 for SqCCs (P < 0.001 between benign and SqCC). Whereas, the SUVmax of [18F]FDG were 2.38 ± 2.27 for benign lesions, 6.63 ± 4.24 for adenocarcinomas (n.s.), and 7.52 ± 2.84 for SqCCs (n.s.). The relationship between TNM tumor stage and the SUVmax of [11C]4DST were 2.54 ± 0.37 for T1, 3.48 ± 0.57 for T2, and 4.17 ± 0.72 for T3 (P < 0.005 between T1 and T2, and P < 0.001 between T1 and T3). In comparison with the TNM pathological stage, SUVmax of [11C]4DST were 2.63 ± 0.49 for stage I, 3.36 ± 0.23 for stage II, 3.40 ± 1.12 for stage III, and 4.65 for stage IV (P < 0.05 between stages I and II). In comparison of the clinical outcome, the SUVmax of [11C]4DST were 2.72 ± 0.56 for the no recurrence (No Rec.) group, 3.10 ± 0.33 for the recurrence-free with adjuvant chemotherapy after the surgery (the No Rec. Adjv. CTx. group) and 4.66 ± 0.02 for the recurrence group (Rec. group) (P < 0.001 between the No Rec and Rec. groups, and P < 0.005 between the No Rec. Adjv. CTx. and Rec. groups).\nConclusions: PET/CT with [11C]4DST is as feasible for imaging of lung tumors as [18F]FDG PET/CT. For diagnosing lung tumors, [11C]4DST PET is useful in distinguishing benign nodules from malignancies. [11C]4DST uptake in lung carcinomas is correlated with the proliferative activity of tumors, indicating a promising noninvasive PET imaging of DNA synthesis in malignant lung tumors.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Japan"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33387282","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12149-020-01554-8","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://link.springer.com/article/10.1007/s12149-020-01554-8","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-7187","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishii, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"1012382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"1012383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sudo, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"1012384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Togawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"1012385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuyama, Junpei"}],"nameIdentifiers":[{"nameIdentifier":"1012386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tani, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"1012387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Takamasa"}],"nameIdentifiers":[{"nameIdentifier":"1012388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Masato"}],"nameIdentifiers":[{"nameIdentifier":"1012389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iizasa, Toshihiko"}],"nameIdentifiers":[{"nameIdentifier":"1012390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shingyoji, Masato"}],"nameIdentifiers":[{"nameIdentifier":"1012391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itami, Makiko"}],"nameIdentifiers":[{"nameIdentifier":"1012392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"1012393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"1012394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamazaki, Kana"}],"nameIdentifiers":[{"nameIdentifier":"1012395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamura, Kentaro"}],"nameIdentifiers":[{"nameIdentifier":"1012396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"1012397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuichi, Nishii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuneo, Saga","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitomi, Sudo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshiaki, Tani","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamasa, Maeda","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kana, Yamazaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kentaro, Tamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuya, Higashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012405","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical value of PET/CT with carbon-11 4DST in the evaluation of malignant and benign lung tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical value of PET/CT with carbon-11 4DST in the evaluation of malignant and benign lung tumors"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-04"},"publish_date":"2020-12-04","publish_status":"0","recid":"81842","relation_version_is_last":true,"title":["Clinical value of PET/CT with carbon-11 4DST in the evaluation of malignant and benign lung tumors"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:56:12.156541+00:00"}