{"created":"2023-05-15T15:00:16.196909+00:00","id":81794,"links":{},"metadata":{"_buckets":{"deposit":"95746723-0f99-4f5a-b416-c2b3b71a78bc"},"_deposit":{"created_by":1,"id":"81794","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81794"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081794","sets":["1"]},"author_link":["1010508","1010503","1010509","1010505","1010497","1010494","1010496","1010493","1010489","1010495","1010504","1010498","1010499","1010506","1010491","1010501","1010500","1010502","1010490","1010507","1010492"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"510","bibliographicPageStart":"502","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study was to assess the feasibility of planning dose-volume histogram (DVH) parameters in computed tomography-based 3D image-guided brachytherapy for locally advanced cervical cancer. In a prospective multi-institutional study, 60 patients with stage IIA2-IVA cervical cancer from eight institutions were treated with external beam radiotherapy using central shielding and intracavitary or hybrid (combined intracavitary/interstitial) brachytherapy (HBT). The dose constraints were set as a cumulative linear quadratic equivalent dose (EQD2) of at least 60 Gy for high-risk clinical target volume (HR-CTV) D90, D2cc ≤ 75 Gy for rectum, D2cc ≤ 90 Gy for bladder and D2cc ≤ 75 Gy for sigmoid. The median HR-CTV D90 was 70.0 Gy (range, 62.8-83.7 Gy) in EQD2. The median D2cc of rectum, bladder and sigmoid was 57.1 Gy (range, 39.8-72.1 Gy), 68.9 Gy (range, 46.5-84.9 Gy) and 57.2 Gy (range, 39.2-71.2 Gy) in EQD2, respectively. In 76 of 233 sessions (33%), 23 patients underwent HBT, and the median number of interstitial needles was 2 (range, 1-5). HBT for a bulky HR-CTV (≥40 cm3) significantly improved the HR-CTV D90 compared with intracavitary brachytherapy alone (P = 0.010). All patients fulfilled the dose constrains for target and at risk organs by undergoing HBT in one-third of sessions. We conclude that the planning DVH parameters used in our protocol are clinically feasible. ","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"  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Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"1010496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daisaku, Yoshida"}],"nameIdentifiers":[{"nameIdentifier":"1010497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriyuki, Okonogi"}],"nameIdentifiers":[{"nameIdentifier":"1010498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isohashi, Fumiaki"}],"nameIdentifiers":[{"nameIdentifier":"1010499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masaru, Wakatsuki"}],"nameIdentifiers":[{"nameIdentifier":"1010500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takashi, Nakano"}],"nameIdentifiers":[{"nameIdentifier":"1010501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuya, Ohno","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ken, Ando","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazutoshi, Murata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shingo, Kato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daisaku, Yoshida","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriyuki, Okonogi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masaru, Wakatsuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takashi, Nakano","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010509","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dosimetric feasibility of computed tomography-based image-guided brachytherapy in locally advanced cervical cancer: a Japanese prospective multi-institutional study ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dosimetric feasibility of computed tomography-based image-guided brachytherapy in locally advanced cervical cancer: a Japanese prospective multi-institutional study "}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-02-08"},"publish_date":"2021-02-08","publish_status":"0","recid":"81794","relation_version_is_last":true,"title":["Dosimetric feasibility of computed tomography-based image-guided brachytherapy in locally advanced cervical cancer: a Japanese prospective multi-institutional study "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:03:43.047528+00:00"}