@article{oai:repo.qst.go.jp:00081689,
 author = {Koshiyama, Daisuke and Okada, Naohiro and Ando, Shuntaro and Koike, Shinsuke and Yahata, Noriaki and Morita, Kentaro and Sawada, Kingo and Morita, Susumu and Kawakami, Shintaro and Kanata, Sho and Fujikawa, Shinya and Sugimoto, Noriko and Toriyama, Rie and Masaoka, Mio and Araki, Tsuyoshi and Kano, Yukiko and Endo, Kaori and Yamasaki, Syudo and Nishida, Atsushi and Mariko, Hiraiwa-Hasegawa and Kasai, Kiyoto and Noriaki, Yahata},
 journal = {NeuroImage},
 month = {Jan},
 note = {Maternal breastfeeding has an impact on motor and emotional development in children of the next generation. Elucidating how breastfeeding during infancy affects brain regional structural development in early adolescence will be helpful for promoting healthy development. However, previous studies that have shown relationships between breastfeeding during infancy and cortical brain regions in adolescence are usually based on maternal retrospective recall of breastfeeding, and the accuracy of the data is unclear. In this study, we investigated the association between breastfeeding duration and brain regional volume in a population-neuroimaging study of early adolescents in Japan (N ​= ​207; 10.5-13.4 years) using voxel-based morphometry, which enabled us to analyze the whole brain. We evaluated breastfeeding duration as indexed by maternal and child health handbook records during infancy. The results showed a significant positive correlation between the duration of breastfeeding and gray matter volume in the dorsal and ventral striatum and the medial orbital gyrus. Post hoc exploratory analyses revealed that the duration of breastfeeding was significantly correlated with emotional behavior. Additionally, the volume in the medial orbital gyrus mediated an association between breastfeeding duration and emotional behavior. This is the first study to evaluate the effect of breastfeeding during infancy on regional brain volumes in early adolescence based on maternal and child health handbook records. Our findings shed light upon the importance of maternal breastfeeding for brain development related to emotional and motivational processing in early adolescence.},
 title = {Association between duration of breastfeeding based on maternal reports and dorsal and ventral striatum and medial orbital gyrus volumes in early adolescence.},
 volume = {220},
 year = {2020}
}