{"created":"2023-05-15T15:00:08.438170+00:00","id":81616,"links":{},"metadata":{"_buckets":{"deposit":"5993f9be-1144-43f0-9f5f-ccf8eda5c10a"},"_deposit":{"created_by":1,"id":"81616","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81616"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081616","sets":["1"]},"author_link":["1009269","1009275","1009280","1009284","1009283","1009276","1009277","1009271","1009278","1009273","1009282","1009267","1009270","1009274","1009281","1009268","1009272","1009266","1009279"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"149","bibliographicPageStart":"123","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"Journal of Medicinal Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The endocannabinoid system (ECS) is involved in a wide range of biological functions and is comprised of cannabinoid receptors and enzymes responsible for endocannabinoid synthesis and degradation. Besides its physiological role, the ECS has been implicated in the development and pathophysiology of a number of central nervous system and peripheral diseases. Over the past two decades, significant advances towards developing drugs and positron emission tomography (PET) tracers targeting different components of the ECS have been made, some of which have entered clinical trials. Herein, we summarized the recent development of PET tracers for imaging cannabinoid receptors 1 (CB1R) and 2 (CB2R) as well as the key enzymes monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH). Given the importance of the ECS for neuronal function, particular focus will be devoted to neuroimaging applications. State-of-the-art PET tracers for the ECS will be reviewed including their chemical design, pharmacological properties, radiolabeling strategies, as well as preclinical and human PET imaging. In addition, this review addresses the current challenges for ECS PET biomarker development and highlights the important role of PET ligands to study disease pathophysiology as well as to facilitate drug discovery.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS Publications"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.jmedchem.0c01459","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01459","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-2623","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hou, Lu"}],"nameIdentifiers":[{"nameIdentifier":"1009266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Rong, Jian"}],"nameIdentifiers":[{"nameIdentifier":"1009267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Haider, Ahmed"}],"nameIdentifiers":[{"nameIdentifier":"1009268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogasawara, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"1009269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Varlow, Cassis"}],"nameIdentifiers":[{"nameIdentifier":"1009270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Schafroth, Michael"}],"nameIdentifiers":[{"nameIdentifier":"1009271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mu, Linjing"}],"nameIdentifiers":[{"nameIdentifier":"1009272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gan, Jiefeng"}],"nameIdentifiers":[{"nameIdentifier":"1009273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xu, Hao"}],"nameIdentifiers":[{"nameIdentifier":"1009274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"J. Fowler, Christopher"}],"nameIdentifiers":[{"nameIdentifier":"1009275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"1009276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vasdev, Neil"}],"nameIdentifiers":[{"nameIdentifier":"1009277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ametamey, Simon"}],"nameIdentifiers":[{"nameIdentifier":"1009278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"F. Cravatt, Benjamin"}],"nameIdentifiers":[{"nameIdentifier":"1009279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lu, Wang"}],"nameIdentifiers":[{"nameIdentifier":"1009280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liang, Huan"}],"nameIdentifiers":[{"nameIdentifier":"1009281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lu, Wang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liang, Huan","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009284","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-10"},"publish_date":"2020-12-10","publish_status":"0","recid":"81616","relation_version_is_last":true,"title":["Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:08:27.502664+00:00"}