{"created":"2023-05-15T15:00:07.899624+00:00","id":81604,"links":{},"metadata":{"_buckets":{"deposit":"4d85e237-d5bd-4aa3-9c96-46176e08905d"},"_deposit":{"created_by":1,"id":"81604","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81604"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081604","sets":["10:28"]},"author_link":["916825","916824","916822","916826","916827","916828","916821","916823"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-11-09","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study investigated positron emission tomography (PET) agents, which can be bind to Glutamate Transporter (GLT) from amino acid structures. The original amino acids passes through the transporter. Alternatively, focusing only on binding to GLT from the calculation results, the permeability of the blood-brain barrier (BBB) decreased. This study established the synthesis of the GLT imaging agent using an in silico binding assay and addressed the permeability of the BBB using lipid solubility and the molecular size of structural compounds.\n\nFrom the in silico binding assay, we derived the binding structure of GLT adding the conditions for BBB permeability and studied the labeling of PET tracers using 11C or 18F radioisotopes. Currently, this method can be applied to sequencing, label synthesis, and animal experiments.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第57回ペプチド討論会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamaguchi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"916821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamashiro, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"916822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Maki"}],"nameIdentifiers":[{"nameIdentifier":"916823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karuo, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"916824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Omote, Masaaki"}],"nameIdentifiers":[{"nameIdentifier":"916825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Katsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"916826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"916827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Maki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"916828","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"AMINO ACID DERIVATIVE DESIGN USING COMPUTATIONAL CHEMISTRY AND APPLICATION TO PET TRACER","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AMINO ACID DERIVATIVE DESIGN USING COMPUTATIONAL CHEMISTRY AND APPLICATION TO PET TRACER"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-08"},"publish_date":"2021-01-08","publish_status":"0","recid":"81604","relation_version_is_last":true,"title":["AMINO ACID DERIVATIVE DESIGN USING COMPUTATIONAL CHEMISTRY AND APPLICATION TO PET TRACER"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:56:56.095388+00:00"}