@article{oai:repo.qst.go.jp:00081576, author = {Nakanishi, Ikuo and Shoji, Yoshimi and Ueno, Megumi and Matsuoka, Yuta and Ken-ichi, Yamada and Ken-ichiro, Matsumoto and Nakanishi, Ikuo and Shoji, Yoshimi and Ueno, Megumi and Matsumoto, Kenichiro}, issue = {HIMAC-148}, journal = {2019年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書}, month = {Nov}, note = {The effect of the plateau region carbon ion (C-ion) beams (13 keV/µm) on lipid molecules was investigated by 2,2,6-trimethyl-4-(4-nitrobenzo[1,2,5]oxadiazol-7-ylamino)-6-pentylpiperidine-1-oxyl (NBD-Pen), a highly selective fluorescence probe for lipid radicals with high sensitivity. An increase in the fluorescence intensity due to lipid radical adducts of NBD-Pen was observed for the isopropyl myristate (IPM) and acetonitrile (MeCN) solutions of NBD-Pen after the plateau region C-ion irradiation, while such an increase was not observed for a methanol (MeOH) solution of NBD-Pen. A slight increase in the fluorescence intensity was observed after 30 Gy plateau region C-ion irradiation to phosphate buffer solutions containing unsaturated fatty acids, such as linoleic acid (LA) and alpha-linoleic acid (ALA), and NBD-Pen.}, pages = {119--120}, title = {Effect of Plateau Carbon-Ion Beams on Lipid Molecules}, volume = {QST-R-17}, year = {2020} }