{"created":"2023-05-15T15:00:05.542244+00:00","id":81549,"links":{},"metadata":{"_buckets":{"deposit":"df64642a-b75c-474b-bee2-6bd9c2dd00f4"},"_deposit":{"created_by":1,"id":"81549","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81549"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081549","sets":["1"]},"author_link":["1012098","1012100","1012102","1012096","1012094","1012091","1012097","1012101","1012095","1012092","1012093","1012099"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"580127","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"frontiers in Neurology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Caffeine is considered to be a neuroprotective agent against Parkinson’s disease (PD)\nand is expected to offer a blood-based biomarker for the disease.We herein investigated\nthe ability of this biomarker to discriminate between PD and neurodegenerative diseases.\nTo quantify caffeine concentrations in serum and plasma, we developed a specific\ncompetitive enzyme-linked immunosorbent assay (ELISA). To validate the diagnostic\nperformance of the assay, we conducted a case control-study of two independent\ncohorts among controls and patients with PD and multiple system atrophy (MSA).\nParallelism, recovery rate, and intra- and inter-assay precision of our assay were within\nthe standard of acceptance. In the first cohort of 31 PD patients, 18 MSA patients and 33\nage-matched controls, serum caffeine levels were significantly lower in PD patients than\nin Controls (p = 0.018). A similar trend was also observed in the MSA group, but did not\nreach the level of significance. In the second cohort of 50 PD patients, 50 MSA patients\nand 45 age-matched controls, plasma caffeine levels were significantly decreased in\nboth PD and MSA groups compared to Controls (p < 0.001). This originally developed\nELISA offered sufficient sensitivity to detect caffeine in human serum and plasma. We\nreproducibly confirmed decreased blood concentrations of caffeine in PD compared to\ncontrols using this ELISA. A similar trend was observed in the MSA group, despite a lack\nof consistent significant differences across cohorts.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33414755","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3389/fneur.2020.580127","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.frontiersin.org/articles/10.3389/fneur.2020.580127/full","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1664-2295","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohmichi, Takuma"}],"nameIdentifiers":[{"nameIdentifier":"1012091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kasai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"1012092","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinomoto, Makiko"}],"nameIdentifiers":[{"nameIdentifier":"1012093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuura, Jun"}],"nameIdentifiers":[{"nameIdentifier":"1012094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koizumi, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"1012095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukiko, Kitani-Morii"}],"nameIdentifiers":[{"nameIdentifier":"1012096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatebe, Harutsugu"}],"nameIdentifiers":[{"nameIdentifier":"1012097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Hidenao"}],"nameIdentifiers":[{"nameIdentifier":"1012098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizuno, Toshiki"}],"nameIdentifiers":[{"nameIdentifier":"1012099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokuda, Takahiko"}],"nameIdentifiers":[{"nameIdentifier":"1012100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harutsugu, Tatebe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahiko, Tokuda","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012102","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Quantification of Blood Caffeine Levels in Patients With Parkinson's Disease and Multiple System Atrophy by Caffeine ELISA","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Quantification of Blood Caffeine Levels in Patients With Parkinson's Disease and Multiple System Atrophy by Caffeine ELISA"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-05"},"publish_date":"2021-01-05","publish_status":"0","recid":"81549","relation_version_is_last":true,"title":["Quantification of Blood Caffeine Levels in Patients With Parkinson's Disease and Multiple System Atrophy by Caffeine ELISA"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:57:11.375291+00:00"}