{"created":"2023-05-15T15:00:05.497098+00:00","id":81548,"links":{},"metadata":{"_buckets":{"deposit":"ee73b365-04f1-4c69-87b9-6d950e8fc305"},"_deposit":{"created_by":1,"id":"81548","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81548"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081548","sets":["1"]},"author_link":["1013700","1013699","1013693","1013698","1013694","1013702","1013697","1013701","1013696","1013695"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"104816","bibliographicVolumeNumber":"139","bibliographic_titles":[{"bibliographic_title":"Neurochemistry International"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Patients with Parkinson’s disease (PD) show a common progressive neurodegenerative movement disorder\ncharacterized by rigidity, tremors, postural instability, and bradykinesia due to the loss of dopaminergic neurons\nin the substantia nigra, and is often accompanied by several non-motor symptoms, called parkinsonism. Several\nlines of recent evidence support the hypothesis that mutations in the gene encoding phosphoglycerate kinase\n(PGK) play an important role in the PD mechanism. PGK is a key enzyme in the glycolytic pathway that catalyzes\nthe reaction from 1,3-diphosphoglycerate to 3-phosphoglycerate. We herein established a parkinsonism model\ntargeting Drosophila Pgk. Dopaminergic (DA) neuron-specific Pgk knockdown lead to locomotive defects in both\nyoung and aged adult flies and was accompanied by progressive DA neuron loss with aging. Pgk knockdown in\nDA neurons decreased dopamine levels in the central nervous system (CNS) of both young and aged adult flies.\nThese phenotypes are similar to the defects observed in human PD patients, suggesting that the Pgk knockdown\nflies established herein are a promising model for parkinsonism. Furthermore, pan-neuron-specific Pgk knockdown\ninduced low ATP levels and the accumulation of reactive oxygen species (ROS) in the CNS of third instar\nlarvae. Collectively, these results indicate that a failure in the energy production system of Pgk knockdown flies\ncauses locomotive defects accompanied by neuronal dysfunction and degeneration in DA neurons.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32758590","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neuint.2020.104816.","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/abs/pii/S0197018620302072","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0197-0186","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Joe"}],"nameIdentifiers":[{"nameIdentifier":"1013693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kasai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"1013694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"1013695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"M. Huynh, Anh"}],"nameIdentifiers":[{"nameIdentifier":"1013696","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yumiko, Nakao-Azuma"}],"nameIdentifiers":[{"nameIdentifier":"1013697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinomoto, Makiko"}],"nameIdentifiers":[{"nameIdentifier":"1013698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokuda, Takahiko"}],"nameIdentifiers":[{"nameIdentifier":"1013699","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizuno, Toshiki"}],"nameIdentifiers":[{"nameIdentifier":"1013700","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Masamitsu"}],"nameIdentifiers":[{"nameIdentifier":"1013701","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahiko, Tokuda","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1013702","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Novel Drosophila model for parkinsonism by targeting phosphoglycerate kinase","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel Drosophila model for parkinsonism by targeting phosphoglycerate kinase"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-05"},"publish_date":"2021-01-05","publish_status":"0","recid":"81548","relation_version_is_last":true,"title":["Novel Drosophila model for parkinsonism by targeting phosphoglycerate kinase"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:51:16.225522+00:00"}