@article{oai:repo.qst.go.jp:00081546,
 author = {Yu-ichi, Noto and Masaki Kondo and Tsuji, Yukiko and Matsushima, Shigenori and Mizuno, Toshiki and Tokuda, Takahiko and Nakagawa, Masanori and Takahiko, Tokuda},
 journal = {Frontiers in Neurology},
 month = {Jan},
 note = {Background: The accumulation of multiple-protein aggregates within muscle fibers is a pathological hallmark of sporadic inclusion body myositis (s-IBM) with the presence of inclusion bodies. Amyloid-beta is one of the accumulated proteins in s-IBM. The aim of this study was to elucidate the utility of Pittsburgh compound B-positron emission tomography (PIB-PET) for diagnosing s-IBM.

Methods: Nine patients with s-IBM and four patients with idiopathic inflammatory myopathy (IIM) were included. Patients underwent PIB-PET of body muscles. Standardized uptake values (SUVs) were measured in 16 muscles. A comparison of SUVs was made between s-IBM and IIM groups. The correlation between PIB-PET and clinical parameters was analyzed.

Results: The mean SUV of all muscles in s-IBM patients was higher than in IIM patients (0.32 vs. 0.25, respectively; p = 0.031). Subgroup analysis identified a clear difference in SUVs of the forearm and lower-leg muscle groups (p = 0.021 and p = 0.045, respectively). There was no correlation between SUVs and clinical parameters in s-IBM patients.

Conclusions: Muscle PIB-PET may help to make a diagnosis of s-IBM.},
 title = {Diagnostic Value of Muscle [11C] PIB-PET in Inclusion Body Myositis},
 volume = {10},
 year = {2020}
}