{"created":"2023-05-15T15:00:05.271368+00:00","id":81542,"links":{},"metadata":{"_buckets":{"deposit":"10b22341-5f2c-4edc-b39d-03a4370a67de"},"_deposit":{"created_by":1,"id":"81542","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81542"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081542","sets":["10:28"]},"author_link":["915397","915394","915395","915398","915399","915393","915396","915400"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-02-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) are genetically modified G-protein coupled receptors that are activated by physiologically inert designer drugs. Two types of muscarinic-based designer receptor, such as hM3Dq (excitatory) and hM4Di (inhibitory), are widely used and remotely modulate the neural activity of a target cell population expressing a \"designer receptor\" by systemic delivery of a designer drug (CNO). \n We have shown that positron emission tomography (PET) with [11C]clozapine enables us to monitor the hM4Di expression and the agonist dose–occupancy relationship that provides critical information for successful chemogenetic silencing (Nagai et al., 2016). However, previous designer-drugs suffer from low selectivity and poor metabolic stability.\n Here we developed a novel ligand, deschloroclozapine (DCZ), served a dual purpose in chemogenetics: (1) as a selective compound for visualization of DREADD expression in vivo by PET and (2) as a selective agonist for muscarinic-based DREADDs.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第6回 CiNet Conference Brain-Machine Interface  - Medical Engineering based on Neuroscience -","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永井, 裕司"}],"nameIdentifiers":[{"nameIdentifier":"915393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮川, 尚久"}],"nameIdentifiers":[{"nameIdentifier":"915394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"堀, 由紀子"}],"nameIdentifiers":[{"nameIdentifier":"915395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南本, 敬史"}],"nameIdentifiers":[{"nameIdentifier":"915396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagai, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"915397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyakawa, Naohisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"915398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hori, Yukiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"915399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamimoto, Takafumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"915400","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A novel chemogenetic agnoist \"Deschloroclozapine\" selectively visualizes and activates chemogenetic receptors in non-human primates","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A novel chemogenetic agnoist \"Deschloroclozapine\" selectively visualizes and activates chemogenetic receptors in non-human primates"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-05"},"publish_date":"2021-01-05","publish_status":"0","recid":"81542","relation_version_is_last":true,"title":["A novel chemogenetic agnoist \"Deschloroclozapine\" selectively visualizes and activates chemogenetic receptors in non-human primates"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:58:28.460945+00:00"}