{"created":"2023-05-15T15:00:04.816371+00:00","id":81530,"links":{},"metadata":{"_buckets":{"deposit":"29723e85-8ca4-4bb4-afa6-0999ed721330"},"_deposit":{"created_by":1,"id":"81530","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81530"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081530","sets":["1"]},"author_link":["1016545","1016543","1016533","1016534","1016538","1016537","1016544","1016542","1016547","1016541","1016536","1016546","1016539","1016535","1016540"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"1","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Acta Neuropathologica Communications"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Microglia-mediated neuroinflammation has been implicated in the pathogenesis of Alzheimer’s disease (AD).\nAlthough microglia in aging and neurodegenerative disease model mice show a loss of homeostatic phenotype\nand activation of disease-associated microglia (DAM), a correlation between those phenotypes and the degree of\nneuronal cell loss has not been clarified. In this study, we performed RNA sequencing of microglia isolated from three\nrepresentative neurodegenerative mouse models, AppNL-G-F/NL-G-F with amyloid pathology, rTg4510 with tauopathy,\nand SOD1G93A with motor neuron disease by magnetic activated cell sorting. In parallel, gene expression patterns\nof the human precuneus with early Alzheimer’s change (n = 11) and control brain (n = 14) were also analyzed by\nRNA sequencing. We found that a substantial reduction of homeostatic microglial genes in rTg4510 and SOD1G93A\nmicroglia, whereas DAM genes were uniformly upregulated in all mouse models. The reduction of homeostatic\nmicroglial genes was correlated with the degree of neuronal cell loss. In human precuneus with early AD pathology,\nreduced expression of genes related to microglia- and oligodendrocyte-specific markers was observed, although the\nexpression of DAM genes was not upregulated. Our results implicate a loss of homeostatic microglial function in the\nprogression of AD and other neurodegenerative diseases. Moreover, analyses of human precuneus also suggest loss\nof microglia and oligodendrocyte functions induced by early amyloid pathology in human","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BMC"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33402227","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s40478-020-01099-x","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-020-01099-x","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2051-5960","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sobue, Akira"}],"nameIdentifiers":[{"nameIdentifier":"1016533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komine, Okiru"}],"nameIdentifiers":[{"nameIdentifier":"1016534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Yuichiro"}],"nameIdentifiers":[{"nameIdentifier":"1016535","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Fumito"}],"nameIdentifiers":[{"nameIdentifier":"1016536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizoguchi, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"1016537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Seiji"}],"nameIdentifiers":[{"nameIdentifier":"1016538","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murayama, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"1016539","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"1016540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"C. Saido, Takaomi"}],"nameIdentifiers":[{"nameIdentifier":"1016541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko"}],"nameIdentifiers":[{"nameIdentifier":"1016542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"1016543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogi, Tomoo"}],"nameIdentifiers":[{"nameIdentifier":"1016544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamanaka, Koji"}],"nameIdentifiers":[{"nameIdentifier":"1016545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naruhiko, Sahara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016547","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-05"},"publish_date":"2021-01-05","publish_status":"0","recid":"81530","relation_version_is_last":true,"title":["Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:39:59.112609+00:00"}