{"created":"2023-05-15T15:00:02.759925+00:00","id":81484,"links":{},"metadata":{"_buckets":{"deposit":"a3b70aaa-97fb-4d55-8d46-1f430954e076"},"_deposit":{"created_by":1,"id":"81484","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81484"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081484","sets":["1"]},"author_link":["1013657","1013656","1013664","1013659","1013663","1013660","1013662","1013658","1013661"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"110","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Journal of Personalized Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Micronuclei (MN) trigger antitumor immune responses via the cyclic GMP-AMP synthase-signaling effector stimulator of interferon genes (cGAS-STING) pathway. Radiotherapy induces MN in peripheral blood lymphocytes. However, data for solid tumors are lacking. Here, we analyzed MN post-radiotherapy in solid tumor samples. Tumor biopsy specimens were obtained from seven prospectively recruited patients with cervical cancer, before treatment and after receiving radiotherapy at a dose of 10 Gy (in five fractions). The samples were stained with 4′,6-diamidino-2-phenylindole dihydrochloride, and 200 nuclei per sample were randomly identified and assessed for the presence of MN or apoptosis, based on nuclear morphology. The median number of MN-harboring nuclei was significantly greater in samples from patients treated with radiotherapy than in pre-treatment samples (151 (range, 16–327) versus 28 (range, 0–61); p = 0.015). No significant differences in the number of apoptotic nuclei were observed between pre-treatment and 10 Gy samples (5 (range, 0–30) versus 12 (range, 2–30); p = 0.30). This is the first report to demonstrate MN induction by radiotherapy in solid tumors. The results provide clinical evidence of the activation of antitumor immune responses by radiotherapy","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/jpm10030110","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/2075-4426/10/3/110","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2075-4426","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobayashi, Daijiro"}],"nameIdentifiers":[{"nameIdentifier":"1013656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oike, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"1013657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murata, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"1013658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"1013659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirota , Yuka"}],"nameIdentifiers":[{"nameIdentifier":"1013660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Hiro"}],"nameIdentifiers":[{"nameIdentifier":"1013661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"1013662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"1013663","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazutoshi, Murata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1013664","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Induction of Micronuclei in Cervical Cancer Treated with Radiotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Induction of Micronuclei in Cervical Cancer Treated with Radiotherapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-28"},"publish_date":"2020-12-28","publish_status":"0","recid":"81484","relation_version_is_last":true,"title":["Induction of Micronuclei in Cervical Cancer Treated with Radiotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:51:29.247792+00:00"}