{"created":"2023-05-15T14:59:57.730744+00:00","id":81366,"links":{},"metadata":{"_buckets":{"deposit":"e96baffa-b2e7-4d5b-9175-a03960d4913d"},"_deposit":{"created_by":1,"id":"81366","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81366"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081366","sets":["10:28"]},"author_link":["921944","921934","921940","921938","921933","921935","921936","921941","921937","921939","921943","921942"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-12-23","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"放射線は飛跡に沿って分子を電離することから，照射された細胞では，飛跡と重なるDNA部位に高密度な損傷（クラスターダメージ）が生じると考えられている。しかし，実験的に高密度損傷の存在を実証した研究はなかった。そこで申請者はこれまでに、原子間力顕微鏡（AFM）を用いクラスター損傷を個別に可視化・検出方法を確立し、放射線を照射したプラスミドに生じた損傷の解析を行い、LETの増加によりクラスターダメージを伴う損傷が増加している事を明らかにし、これについて前年度の学会で報告した。その後さらに系を発展させ、AFMによるDNA損傷の可視化分析技術を発展的に展開し、放射線を照射した細胞や腫瘍中のDNAでも検討する方法を確立し、細胞や腫瘍中に生じた塩基損傷、クラスターダメージ、DSB末端に塩基損傷を含む新たなDNA損傷の観察を可能にした。さらに、本発表では、この系を軸に損傷毎の修復速度を解析した。 ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"量子生命科学会第二回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中野, 敏彰"}],"nameIdentifiers":[{"nameIdentifier":"921933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"赤松, 憲"}],"nameIdentifiers":[{"nameIdentifier":"921934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鹿園直哉"}],"nameIdentifiers":[{"nameIdentifier":"921935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山, 亮一"}],"nameIdentifiers":[{"nameIdentifier":"921936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"玉田, 太郎"}],"nameIdentifiers":[{"nameIdentifier":"921937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣本, 武史"}],"nameIdentifiers":[{"nameIdentifier":"921938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshiaki, Nakano","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"921939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ken, Akamatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"921940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naoya, Shikazono","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"921941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryoichi, Hirayama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"921942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taro, Tamada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"921943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeshi, Hiromoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"921944","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"細胞への放射線照射によってDNA中に生じた損傷の可視化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞への放射線照射によってDNA中に生じた損傷の可視化"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-21"},"publish_date":"2020-12-21","publish_status":"0","recid":"81366","relation_version_is_last":true,"title":["細胞への放射線照射によってDNA中に生じた損傷の可視化"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:50:48.482372+00:00"}