{"created":"2023-05-15T14:59:48.839965+00:00","id":81167,"links":{},"metadata":{"_buckets":{"deposit":"5f0dc990-8b45-4719-8c54-a112a847ae5b"},"_deposit":{"created_by":1,"id":"81167","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81167"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081167","sets":["1"]},"author_link":["995470","995467","995468","995469","995471","995472"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"247","bibliographicPageStart":"229","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"放射線生物研究"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"α線内用療法は、α線を放出する核種やそれを標識した化合物を用いて、全身に転移したがんを治療する方法である。全身転移したがんを寛解する臨床成果が得られ、今後の進展が期待されている。このα線内用療法では、外照射による放射線治療とは異なり、腫瘍細胞選択的にRIを取り込ませるドラッグデリバリーにより、高LET放射線であるα線を直接細胞に照射し治療を行う。そのため、ドラッグデリバリーの状況等により不均一な照射場が生じる可能性があり、バイスタンダー効果等の影響を検討する必要がある。本稿では、α線内用療法の特徴や課題を、線量評価、標的/非標的効果、分子メカニズムに注目して、放射線生物学的な視点から概説する。","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"放射線生物研究会"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0441-747X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂下, 哲哉"}],"nameIdentifiers":[{"nameIdentifier":"995467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横田, 裕一郎"}],"nameIdentifiers":[{"nameIdentifier":"995468","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島, 康宏"}],"nameIdentifiers":[{"nameIdentifier":"995469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Sakashita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"995470","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuuichiro, Yokota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"995471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuhiro, Oshima","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"995472","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"α線放出核種を用いたRI内用療法と放射線生物学","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"α線放出核種を用いたRI内用療法と放射線生物学"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-29"},"publish_date":"2020-06-29","publish_status":"0","recid":"81167","relation_version_is_last":true,"title":["α線放出核種を用いたRI内用療法と放射線生物学"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:01:36.264953+00:00"}