@misc{oai:repo.qst.go.jp:00081078,
 author = {Ohsawa, Daisuke and Konishi, Teruaki and Ohsawa, Daisuke and Konishi, Teruaki},
 month = {Nov},
 note = {Ion beam therapy continues attracting attention for cancer treatment as compared to conventional radiotherapy such as X-rays or electrons, owing to the beneficial energy deposition with the largest dose in the tumour region, called Bragg peak. Its biological effectiveness is strongly determined by the nanoscopic and stochastic radial energy deposition around individual ion tracks, called track structure. Fluorescent nuclear track detector (FNTD) technology based on Al2O3:C,Mg single crystals in combination with non-destructive read out with confocal laser scanning microscopy has become the latest tool for providing precise 3D information on ion trajectories. In recent years, significant advances in spatial resolution have been made in optical microscopy, in particular, stimulated emission depletion (STED) microscopy, which achieves super resolution that breaks the Abbe's diffraction limit of roughly half the excitation wavelength (~λ/2), allowing for nanoscopic visualization of energy deposition, thus leading to better understanding of track structure. In this study, STED and confocal microscopy was evaluated for imaging of various heavy ion tracks (6~500 MeV/u He, C, Fe) in FNTDs; STED and confocal mode was readily switched using a STEDYCON (Abberior Instruments GmbH) attached to an Olympus IX83 inverted microscope. In this symposium, detail quantitative analysis of primary ions and ejected secondary electrons tracks with two imaging modalities will be discussed. This study was supported in part by a Japan Society for the Promotion of Science (JSPS) KAKENHI Grant-in-Aid for Scientific Research(B) (20H03634)., The 63rd Symposium of The Japanese Society of Microscopy},
 title = {STED microscopy of single ion tracks in a fluorescent nuclear track detector (FNTD) toward super-resolution cellular dosimetry},
 year = {2020}
}