{"created":"2023-05-15T14:59:43.437734+00:00","id":81038,"links":{},"metadata":{"_buckets":{"deposit":"b49f5ea9-e303-4b7c-99de-5b596f2cac45"},"_deposit":{"created_by":1,"id":"81038","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81038"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081038","sets":["10:28"]},"author_link":["907375","907381","907376","907379","907374","907377","907380","907382","907378"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"有用な11C標識中間体である[11C]HCNの製造には、現状では専用の製造機器/設備が必要である。そこで、多くの11C製造施設で用いられている[11C]CH3Iから特別な機器/設備が無くても簡便かつ効率的に[11C]HCNを製造する方法の開発を行った。【方法】[11C]CH3Iを種々のトリアルキルアミンN-オキシド溶液を担持した石英綿に120℃で2分間通じることで[11C]HCHOに変換し、これをヒドロキシルアミン硫酸エステル（HOSA）を担持した石英砂に150℃で2分間通じることで[11C]HCNを得た。各試薬はガラスカラムに保持させ、加熱はシリコンラバーヒーターで行った。【結果】[11C]HCHOの生成において、石英綿に担持させるN-オキシド溶液の溶媒は、スルホキシド系溶媒が適切であった。 [11C]HCHOのHOSAとの反応では無溶媒でも効率的に[11C]HCNが得られた。N-オキシドにオキシマトリンを用いることで、従来の方法と同等の収率かつ十分な比放射能の [11C]HCNが得られた。合成時間は、照射終了から15分以内で完了した。【結論】本方法を用いることで、[11C]CH3Iを製造している施設であれば簡便かつ効率的に[11C]HCNを製造し利用することができる。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第60回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"菊池, 達矢"}],"nameIdentifiers":[{"nameIdentifier":"907374","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"907375","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村, 敏充"}],"nameIdentifiers":[{"nameIdentifier":"907376","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"D. Gee, Antony"}],"nameIdentifiers":[{"nameIdentifier":"907377","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"907378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"907379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Masanao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"907380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamura, Toshimitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"907381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"907382","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]HCNの簡便な製造法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]HCNの簡便な製造法の開発"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-20"},"publish_date":"2020-08-20","publish_status":"0","recid":"81038","relation_version_is_last":true,"title":["[11C]HCNの簡便な製造法の開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:08:31.124654+00:00"}