{"created":"2023-05-15T14:59:41.665504+00:00","id":80996,"links":{},"metadata":{"_buckets":{"deposit":"604d1c31-01e5-4d82-9faa-b3cb997d0705"},"_deposit":{"created_by":1,"id":"80996","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80996"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080996","sets":["10:29"]},"author_link":["900989","901004","900998","900995","900993","901005","901006","900991","900999","900988","900994","900992","901000","901001","901003","901007","900987","900990","900996","901002","901008","900997"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-11-12","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】膵がんは生存率が低く、予後改善のため早期診断・治療法の開発が望まれる。我々は本大会で、64Cu標識抗EGFR抗体（セツキシマブ）腹腔投与を用いた高分解能開放型PET（OpenPET）により、1cm未満の早期膵がんを明瞭に検出できることを報告している。一方、OpenPETは診断のみならず、リアルタイムにPET撮影しながら治療も可能である。本研究では、64Cu標識セツキシマブ腹腔投与のOpenPETガイド手術を行い、有用性を実証した。【方法・結果】早期膵がんマウスモデル（ヒト膵がんxPA-1-RFP細胞使用）を作成し、作成したモデルに64Cu標識セツキシマブ（7.4 MBq）を腹腔投与し24h後リアルタイムOpenPETガイド手術を行った。その結果、本法より肉眼では検出できない膵臓内の微小な膵がん（＞3mm）を術中に明瞭に検出し摘出できることを明らかにした。また、OpenPETガイド手術は本モデルにおける生存を有意に延長した。【結論】リアルタイムOpenPETガイド手術は、膵がんの予後改善に寄与する新規早期診断・治療法になり得ることが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第60回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉井, 幸恵"}],"nameIdentifiers":[{"nameIdentifier":"900987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"五十嵐, 千佳"}],"nameIdentifiers":[{"nameIdentifier":"900988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田島, 英朗"}],"nameIdentifiers":[{"nameIdentifier":"900989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩男, 悠真"}],"nameIdentifiers":[{"nameIdentifier":"900990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 英治"}],"nameIdentifiers":[{"nameIdentifier":"900991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂, 秀克"}],"nameIdentifiers":[{"nameIdentifier":"900992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"赤松, 剛"}],"nameIdentifiers":[{"nameIdentifier":"900993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山谷, 泰賀"}],"nameIdentifiers":[{"nameIdentifier":"900994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"900995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"900996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東, 達也"}],"nameIdentifiers":[{"nameIdentifier":"900997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshii, Yukie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"900998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Igarashi, Chika","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"900999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tashima, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwao, Yuma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akamatsu, Go","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaya, Taiga","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901008","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"64Cu標識セツキシマブによる早期膵がんに対するリアルタイムPETガイド手術法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"64Cu標識セツキシマブによる早期膵がんに対するリアルタイムPETガイド手術法の開発"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-19"},"publish_date":"2020-08-19","publish_status":"0","recid":"80996","relation_version_is_last":true,"title":["64Cu標識セツキシマブによる早期膵がんに対するリアルタイムPETガイド手術法の開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:17:02.190689+00:00"}