{"created":"2023-05-15T14:59:41.621474+00:00","id":80995,"links":{},"metadata":{"_buckets":{"deposit":"b7d2a8ac-5a1b-4dea-a409-d7448d4be487"},"_deposit":{"created_by":1,"id":"80995","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80995"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080995","sets":["10:28"]},"author_link":["904618","904608","904611","904616","904606","904615","904617","904610","904619","904613","904607","904609","904614","904612"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】[11C]MAGL-8は、脳内に広く分布するモノアシルグリセロールリパーゼ（MAGL）と結合後、加水分解され、[11C]CO2となり、脳内から排出される。本研究では、この特性を利用して、pHの低下によるMAGLの活性変化を[11C]CO2の排出速度を指標としてPETイメージングを試みた。\n【方法】はじめに、ラット脳ホモジネートを用いて、pHの違いによる[11C]CO2生成量の変化をインビトロで測定した。次に、脳梗塞モデルラットを用いてPETイメージングを行い、正常側、虚血側の放射能のクリアランス速度をそれぞれ測定した。\n【結果】インビトロでの[11C]CO2生成量はpHが6付近まで低下すると20～30％減少し、5以下になるとMAGLが失活し、[11C]CO2が殆ど生成されなかった。PETイメージングにおいても、虚血側で放射能のクリアランス速度が20～30％減少した。\n【結論】[11C]MAGL-8を用いて、脳内pHを反映したPETイメージングに成功した。\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第60回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"904606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平石, 惇人"}],"nameIdentifiers":[{"nameIdentifier":"904607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"904608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 崇之"}],"nameIdentifiers":[{"nameIdentifier":"904609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"904610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"904611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"904612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"904613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiraishi, Atsuto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"904614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Wakana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"904615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"904616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"904617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"904618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"904619","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"モノアシルグリセロールリパーゼを標的としたPETプローブを用いた脳内pHイメージング法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"モノアシルグリセロールリパーゼを標的としたPETプローブを用いた脳内pHイメージング法の開発"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"80995","relation_version_is_last":true,"title":["モノアシルグリセロールリパーゼを標的としたPETプローブを用いた脳内pHイメージング法の開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:11:55.000759+00:00"}