{"created":"2023-05-15T14:59:41.577215+00:00","id":80994,"links":{},"metadata":{"_buckets":{"deposit":"33fbffae-c907-4dda-941f-ae492623ec5a"},"_deposit":{"created_by":1,"id":"80994","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80994"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080994","sets":["10:28"]},"author_link":["902580","902581","902573","902574","902582","902578","902577","902579","902576","902575"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"NMDA受容体は、イオンチャンネル型グルタミン酸受容体の一種であり、学習や記憶等の機能との関わりが深く、さらに神経保護作用などにも関連しているといわれている。今回我々はNMDAのGluN2Bサイドに対する選択的なPETプローブ[11C]N2B-1810 と [11C]N2B-1903 を合成し、in vitro ARG及び小動物PETなどによる評価を行ったので報告する。非標識体及び標識原料のデスメチル体は、市販試薬より３〜４工程で合成した。標識合成は、[11C]ヨウ化メチルを用いて行い、両プローブともに、放射化学収率、純度は良好であった。両プローブのラット脳のin vitro ARG では、GluN2B の存在が多い大脳皮質、線条体、海馬等に顕著な放射能集積が見られた。また、GluN2B の特異的阻害剤であるBMT-108908及び (+)-CP101606 の処理により、これらの放射能集積は顕著に低下した。今後、PETによる評価を行なう予定である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第60回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"熊田, 勝志"}],"nameIdentifiers":[{"nameIdentifier":"902573","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"902574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"902575","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"902576","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"902577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"902578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"902579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"902580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"902581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"902582","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"脳内NMDA受容体を標的としたPET薬剤の合成と評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳内NMDA受容体を標的としたPET薬剤の合成と評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"80994","relation_version_is_last":true,"title":["脳内NMDA受容体を標的としたPET薬剤の合成と評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:14:46.931605+00:00"}