{"created":"2023-05-15T14:59:41.445376+00:00","id":80991,"links":{},"metadata":{"_buckets":{"deposit":"3a1bd0b3-2496-4034-8531-91f8a42c4a64"},"_deposit":{"created_by":1,"id":"80991","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80991"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080991","sets":["10:29"]},"author_link":["901079","901086","901077","901083","901084","901078","901080","901082","901081","901085"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Leucine rich-repeat kinase(LRRK2)遺伝子は巨大なたんぱく質であり、2019番目のグリシン残基がセリン残基となる突然変異によってキナーゼ活性が増加することが家族性パーキンソン病の原因の1つであると報告されている。近年、LRRK2に対する阻害剤やPETイメージング用プローブが開発されてきているが、まだ臨床で使用されている薬剤はない。本研究では、インダゾール骨格を有する新規化合物1を 18Fで標識合成し、ラットにおける脳内動態について検討を行った。化合物1及びそのbromopyridine前駆体は市販品から5~7工程で合成に成功した。In vitro実験では、1のIC50が1.1 nMであった。標識合成では、DABCO存在下で前駆体の18F化及び脱保護反応の2工程で目的物を効率よく得た。放射化学収率は3-7%(EOS)、比放射能は269 GBq/μmol、放射化学純度は96％以上だった。ラットのPET撮像では、SUV1.5の脳内取り込みがみられたが、特異結合が少なかった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第60回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"901077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"901078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"901079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"901080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"901081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Wakana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901083","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901086","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[18F]で標識したLRRK2をターゲットとした新規PETリガンドの合成及び動物評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[18F]で標識したLRRK2をターゲットとした新規PETリガンドの合成及び動物評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"80991","relation_version_is_last":true,"title":["[18F]で標識したLRRK2をターゲットとした新規PETリガンドの合成及び動物評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:16:57.350887+00:00"}