{"created":"2023-05-15T14:59:41.400950+00:00","id":80990,"links":{},"metadata":{"_buckets":{"deposit":"b8090071-f202-43d8-8c4d-7185ca124560"},"_deposit":{"created_by":1,"id":"80990","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80990"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080990","sets":["10:28"]},"author_link":["901269","901261","901279","901272","901280","901266","901281","901273","901263","901262","901271","901267","901276","901282","901275","901270","901278","901274","901264","901265","901268","901277"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景・目的】SL25.1188は、可逆的選択的モノアミン酸化酵素B（MAO-B）阻害剤であり(Ki for rat brain, 8.5 nM; MAO-A/MAO-B, 84)、その11C標識したトレーサー([11C]SL25.1188)は、新たなMAO-B選択的PET用トレーサーとして期待されている。[11C]SL25.1188は[11C]phosgeneから合成され、3.0~7.5%の放射化学的収率であった。近年、[11C]CO2-fixation法により比較的安定的で高収率(12%)で合成する方法が報告され、臨床利用が進められている。我々は、[11C]SL25.1188を臨床利用するために安定的な製造法及び品質検査法を確立した。【方法】[11C]SL25.1188は、ホスファゼン塩基(BEMP)存在下で[11C]CO2-fixation法により11C標識し、続いて0.2% POCl3で脱水反応を行い、HPLC分取後に注射液とし、品質検査を行った。【結果】[11C]SL25.1188は、18%(n = 8)のRCY（照射終了後25分）で合成できた。放射化学的純度は≧99%、比放射能は70~140 GBq/μmolであった。【結論】比較的高い収率で高い品質の[11C]SL25.1188注射液を安定的に製造できた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第60回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"901261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 裕輝"}],"nameIdentifiers":[{"nameIdentifier":"901262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 崇之"}],"nameIdentifiers":[{"nameIdentifier":"901263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚, 賢士"}],"nameIdentifiers":[{"nameIdentifier":"901264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤代, 智也"}],"nameIdentifiers":[{"nameIdentifier":"901265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"富樫, 隆啓"}],"nameIdentifiers":[{"nameIdentifier":"901266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤, 正敏"}],"nameIdentifiers":[{"nameIdentifier":"901267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"901268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"901269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"901270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"901271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furutsuka, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujishiro, Tomoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Togashi, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Muto, Masatoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Wakana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Masanao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901282","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]SL25.1188の臨床提供に向けた安定的製造法及び品質検査法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]SL25.1188の臨床提供に向けた安定的製造法及び品質検査法の確立"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"80990","relation_version_is_last":true,"title":["[11C]SL25.1188の臨床提供に向けた安定的製造法及び品質検査法の確立"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:16:38.336018+00:00"}