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Oxygen sensing ability of positronium atom for tumor hypoxia imaging
https://repo.qst.go.jp/records/80672
https://repo.qst.go.jp/records/806726a1c8b7f-2cb4-4410-a5b8-5d0a16a69a27
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-02 | |||||
| タイトル | ||||||
| タイトル | Oxygen sensing ability of positronium atom for tumor hypoxia imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shibuya, Kengo
× Shibuya, Kengo× Sato, Haruo× Nishikido, Fumihiko× Takahashi, Miwako× Yamaya, Taiga× Kengo, Shibuya× Fumihiko, Nishikido× Miwako, Takahashi× Taiga, Yamaya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Positronium (Ps), a hydrogen-like atom consisting of a positron and an electron, is efficiently formed in the human body during positron emission tomography (PET) examination, and its decay rate into gamma-ray photons is significantly influenced by the chemical environment, especially the dissolved oxygen concentration (pO2) due to the unpaired electrons. However, the functionality of PET has been underestimated by neglecting the specific information provided by Ps. By comparing the decay rates in O2-, N2-, and air-saturated waters, here we show that Ps probes the absolute value of pO2 with a good linearity and a resolution better than 10 mmHg. This is a sufficient sensitivity for discriminating a hypoxic region in a tumor at approximately 6 mmHg from healthy tissues at approximately 40 mmHg. This method depends only on the fundamental properties of Ps and is independent of specific radiopharmaceuticals. The applications of Ps spin states and reactions will greatly enhance PET functionalities in the next decade. |
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| 書誌情報 |
Communications Physics 巻 ３, p. 173, 発行日 2020-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2399-3650 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s42005-020-00440-z | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s42005-020-00440-z | |||||
