{"created":"2023-05-15T14:59:26.616586+00:00","id":80651,"links":{},"metadata":{"_buckets":{"deposit":"b3e3e335-f013-4e67-8850-ac95cd1146cb"},"_deposit":{"created_by":1,"id":"80651","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80651"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080651","sets":["1"]},"author_link":["1011113","1011118","1011115","1011117","1011119","1011121","1011107","1011106","1011114","1011111","1011116","1011112","1011125","1011108","1011122","1011120","1011124","1011109","1011123","1011110"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"278","bibliographicPageStart":"272","bibliographicVolumeNumber":"153","bibliographic_titles":[{"bibliographic_title":"Radiotherapy and Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and purpose: Several studies have focused on increasing the linear energy transfer (LET) within tumours to achieve higher biological effects in carbon-ion radiotherapy (C-ion RT). However, it remains unclear whether LET affects late complications. We assessed whether physical dose and LET distribution can be specific factors for late rectal complications in C-ion RT. \nMaterials and methods: Overall, 134 patients with uterine carcinomas were registered and retrospectively analysed. Of 134 patients, 132 who were followed up for >6 months were enrolled. The correlations between the relative biological effectiveness (RBE)-weighted dose based on the Kanai model (the ostensible \"clinical dose\"), dose-averaged LET (LETd), or physical dose and rectal complications were evaluated. Rectal complications were graded according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. \nResults: Nine patients developed grade 3 or 4 late rectal complications. Linear regression analysis found that D2cc in clinical dose was the sole risk factor for ≥grade 3 late rectal complications (p = 0.012). The receiver operating characteristic analysis found that D2cc of 60.2 Gy (RBE) was a suitable cut-off value for predicting ≥grade 3 late rectal complications. Among 35 patients whose rectal D2cc was ≥60.2 Gy (RBE), no correlations were found between severe rectal toxicities and LETd alone or physical dose per se. \nConclusion: We demonstrated that severe rectal toxicities were related to the rectal D2cc of the clinical dose in C-ion RT. However, no correlations were found between severe rectal toxicities and LETd alone or physical dose per se. ","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32898559","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.radonc.2020.08.029","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S0167814020307581","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0167-8140","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okonogi, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"1011106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Shinnosuke"}],"nameIdentifiers":[{"nameIdentifier":"1011107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukahori, Mai"}],"nameIdentifiers":[{"nameIdentifier":"1011108","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furuichi, Wataru"}],"nameIdentifiers":[{"nameIdentifier":"1011109","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inaniwa, Taku"}],"nameIdentifiers":[{"nameIdentifier":"1011110","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsufuji, Naruhiro"}],"nameIdentifiers":[{"nameIdentifier":"1011111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Reiko"}],"nameIdentifiers":[{"nameIdentifier":"1011112","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"1011113","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanematsu, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"1011114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"1011115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriyuki, Okonogi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinnosuke, Matsumoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mai, Fukahori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wataru, Furuichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taku, Inaniwa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naruhiro, Matsufuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Reiko, Imai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeru, Yamada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuyuki, Kanematsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Tsuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011125","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dose-averaged linear energy transfer per se does not correlate with late rectal complications in carbon-ion radiotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dose-averaged linear energy transfer per se does not correlate with late rectal complications in carbon-ion radiotherapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-05"},"publish_date":"2020-10-05","publish_status":"0","recid":"80651","relation_version_is_last":true,"title":["Dose-averaged linear energy transfer per se does not correlate with late rectal complications in carbon-ion radiotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:01:32.198844+00:00"}