@article{oai:repo.qst.go.jp:00080604,
 author = {Itahashi, Takashi and Okada, Naohiro and Ando, Shuntaro and Yamasaki, Syudo and Koshiyama, Daisuke and Morita, Kentaro and Yahata, Noriaki and Koike, Shinsuke and Nishida, Atsushi and Kasai, Kiyoto and Ryu-ichiro, Hashimoto and Noriaki, Yahata},
 journal = {NeuroImage},
 month = {Sep},
 note = {The child-parent relationship is a significant factor in an adolescent’s well-being and functional outcomes. Epidemiological evidence indicates that relationships with the father and mother are differentially associated with specific psychobehavioral problems that manifest differentially between boys and girls. Neuroimaging is expected to bridge the gap in understanding such a complicated mapping between the child-parent relationships and adolescents’ problems. However, possible differences in the effects of child-father and child-mother relationships on sexual dimorphism in children’s brains and psychobehavioral problems have not been examined yet. This study used a dataset of 10- to 13-year-old children (N ​= ​93) to reveal the triad of associations among child-parent relationship, brain, and psychobehavioral problems by separately estimating the respective effects of child-father and child-mother relationships on boys and girls. We first fitted general linear models to identify the effects of paternal and maternal relationships in largely different sets of children’s resting-state functional connectivity, which we term paternal and maternal functional brain connectomes (FBCs). We then performed connectome-based predictive modeling (CPM) to predict children’s externalizing and internalizing problems from these parental FBCs. The models significantly predicted a range of girls’ internalizing problems, whereas the prediction of boys’ aggression was also significant using a more liberal uncorrected threshold. A series of control analyses confirmed that CPMs using FBCs associated with peer relationship or family socioeconomic status failed to make significant predictions of psychobehavioral problems. Lastly, a causal discovery method identified causal paths from daughter-mother relationship to maternal FBC, and then to daughter’s internalizing problems. These observations indicate sex-dependent mechanisms linking child-parent relationship, brain, and psychobehavioral problems in the development of early adolescence.},
 title = {Functional connectomes linking child-parent relationships with psychological problems in adolescence},
 volume = {219},
 year = {2020}
}