{"created":"2023-05-15T14:59:24.005758+00:00","id":80590,"links":{},"metadata":{"_buckets":{"deposit":"e5e024b0-dd88-4443-b103-ae4951e1c899"},"_deposit":{"created_by":1,"id":"80590","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80590"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080590","sets":["1"]},"author_link":["1002612","1002615","1002604","1002616","1002613","1002614","1002605","1002602","1002608","1002609","1002610","1002603","1002606","1002607","1002611"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"119575","bibliographicVolumeNumber":"586","bibliographic_titles":[{"bibliographic_title":"International Journal of Pharmaceutics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Stable-isotope-labeled probes suitable for magnetic resonance imaging (MRI) would have various potential medical applications, such as tumor imaging. Here, with the aim of developing MRI probes targeting peptide transporters, we synthesized a series of [19F]dipeptides by introducing one or two fluorine atoms or a trifluoromethyl group into the benzene ring of l-phenylalanyl-ψ[CS-N]-l-alanine (Phe-ψ-Ala), which is resistant to cleavage by peptidases. The mono- and difluoro dipeptides were efficiently transported by PEPT1 and PEPT2. Moreover, (3,5)-difluoro Phe-ψ-Ala was metabolically stable in human hepatocyte culture, and had a low distribution volume in mice. An acute toxicity study in mice revealed no apparent effect on body weight or behavior. The biodistribution and biodynamics of this compound could be clearly visualized by 19F-MRI in vivo, although specific signal enhancement was observed only in the bladder, but not in the tumor of tumor-xenografted mice. Although there was no specific signal enhancement of the tested compound at the tumor, the present study provides some challenging points regarding 19F-MRI probes for future investigation.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ijpharm.2020.119575","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S0378517320305597?via%3Dihub#!","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0378-5173","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Arakawa, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"1002602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"1002603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arai, Kazutaka"}],"nameIdentifiers":[{"nameIdentifier":"1002604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawanishi, Takumi"}],"nameIdentifiers":[{"nameIdentifier":"1002605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nitta, Nobuhiro"}],"nameIdentifiers":[{"nameIdentifier":"1002606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"1002607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Eiko"}],"nameIdentifiers":[{"nameIdentifier":"1002608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yano, Kentaro"}],"nameIdentifiers":[{"nameIdentifier":"1002609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"1002610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumamoto, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"1002611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"1002612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogihara, Takuo"}],"nameIdentifiers":[{"nameIdentifier":"1002613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuhiro, Nitta","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1002614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sayaka, Shibata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1002615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1002616","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Possible utility of peptide-transporter-targeting [19F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Possible utility of peptide-transporter-targeting [19F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-30"},"publish_date":"2020-09-30","publish_status":"0","recid":"80590","relation_version_is_last":true,"title":["Possible utility of peptide-transporter-targeting [19F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:33:16.026476+00:00"}