{"created":"2023-05-15T14:59:10.502600+00:00","id":80288,"links":{},"metadata":{"_buckets":{"deposit":"be991602-bd87-48ef-b9eb-03f4df1928ef"},"_deposit":{"created_by":1,"id":"80288","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80288"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080288","sets":["1"]},"author_link":["883024","883025","883030","883027","883031","883022","883026","883029","883023","883028"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Photodiagnosis and Photodynamic Therapy"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction/Aim\nPhotodynamic therapy (PDT) involves the use of a tumor-specific photosensitizer and laser irradiation, and is one of the treatment options recommended for early centrally located lung cancers, but not yet for peripheral-type lung cancers. We developed a new laser probe, the composite-type optical fiberscope (COF), which allows accurate laser irradiation of a cancer lesion with simultaneous visualization of the lesion. In this study, we attempted a new endobronchial PDT technique using the new laser probe, and evaluated the effectiveness and feasibility of this novel PDT technique for peripheral lung cancers.\n\nMethods\nThis phase I study was conducted in 7 patients with peripheral lung cancers (primary tumor ≤20 mm in diameter). We performed endobronchial PDT for these patients using the new laser probe and talaporfin sodium as the photosensitizer.\n\nResults\nWe performed PDT for 3 patients with peripheral lung cancer using a laser dose of 50 J/cm2 at 120 mW, and confirmed the feasibility of using this dose. Then, we escalated the laser dose to 100 J/cm2 in 4 additional patients. A total of 7 patients met our inclusion criteria. Evaluation at 2 weeks and 3 months after the PDT revealed no complication such as pneumonia or pneumothorax. At the evaluation conducted 6 months later, we found CR in 3 cases and SD in the remaining 4 cases.\n\nConclusion\nPDT was found to be a feasible and non-invasive treatment modality for early peripheral-type lung cancer. In the future, PDT could become a standard treatment option for peripheral-type lung cancer.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.pdpdt.2020.101698","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/abs/pii/S157210002030051X#!","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1572-1000","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Usuda, Jitsuo"}],"nameIdentifiers":[{"nameIdentifier":"883022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"883023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchida, Takaaki"}],"nameIdentifiers":[{"nameIdentifier":"883024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohtani, Keishi"}],"nameIdentifiers":[{"nameIdentifier":"883025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maehara, Sachio"}],"nameIdentifiers":[{"nameIdentifier":"883026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikeda, Norihiko"}],"nameIdentifiers":[{"nameIdentifier":"883027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohsaki, Yoshinobu"}],"nameIdentifiers":[{"nameIdentifier":"883028","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Takaaki"}],"nameIdentifiers":[{"nameIdentifier":"883029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oka, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"883030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oka, Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"883031","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-04"},"publish_date":"2020-08-04","publish_status":"0","recid":"80288","relation_version_is_last":true,"title":["Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:38:15.627657+00:00"}