@article{oai:repo.qst.go.jp:00080288,
 author = {Usuda, Jitsuo and Inoue, Tatsuya and Tsuchida, Takaaki and Ohtani, Keishi and Maehara, Sachio and Ikeda, Norihiko and Ohsaki, Yoshinobu and Sasaki, Takaaki and Oka, Kiyoshi and Oka, Kiyoshi},
 journal = {Photodiagnosis and Photodynamic Therapy},
 month = {Jun},
 note = {Introduction/Aim
Photodynamic therapy (PDT) involves the use of a tumor-specific photosensitizer and laser irradiation, and is one of the treatment options recommended for early centrally located lung cancers, but not yet for peripheral-type lung cancers. We developed a new laser probe, the composite-type optical fiberscope (COF), which allows accurate laser irradiation of a cancer lesion with simultaneous visualization of the lesion. In this study, we attempted a new endobronchial PDT technique using the new laser probe, and evaluated the effectiveness and feasibility of this novel PDT technique for peripheral lung cancers.

Methods
This phase I study was conducted in 7 patients with peripheral lung cancers (primary tumor ≤20 mm in diameter). We performed endobronchial PDT for these patients using the new laser probe and talaporfin sodium as the photosensitizer.

Results
We performed PDT for 3 patients with peripheral lung cancer using a laser dose of 50 J/cm2 at 120 mW, and confirmed the feasibility of using this dose. Then, we escalated the laser dose to 100 J/cm2 in 4 additional patients. A total of 7 patients met our inclusion criteria. Evaluation at 2 weeks and 3 months after the PDT revealed no complication such as pneumonia or pneumothorax. At the evaluation conducted 6 months later, we found CR in 3 cases and SD in the remaining 4 cases.

Conclusion
PDT was found to be a feasible and non-invasive treatment modality for early peripheral-type lung cancer. In the future, PDT could become a standard treatment option for peripheral-type lung cancer.},
 title = {Clinical trial of photodynamic therapy for peripheral-type lung cancers using a new laser device in a pilot study},
 volume = {30},
 year = {2020}
}