@article{oai:repo.qst.go.jp:00080191,
 author = {Fukumura, Toshimitsu and Mori, Wakana and Ogawa, Masanao and Fujinaga, Masayuki and Ming-Rong, Zhang and Toshimitsu, Fukumura and Wakana, Mori and Masanao, Ogawa and Masayuki, Fujinaga and Zhang, Ming-Rong},
 journal = {Nuclear Medicine and Biology},
 month = {Jan},
 note = {Carbon-11-labeled phosgene ([11C]phosgene, [11C]COCl2) is a useful labeling agent that connects two heteroatoms by inserting [11C]carbonyl (11C=O) function in carbamates, ureas, and carbonates, which are components of biologically important heterocyclic compounds and functional groups in drugs as a linker of fragments with in vivo stability. Development of 11C-labeled PET tracers has been performed using [11C]phosgene as a labeling agent. However, [11C]phosgene has not been frequently used for 11C-labeling because preparation of [11C]phosgene required dedicated synthesis apparatus (not commercially available) and had problems in reproducibility and reliability. In our laboratory, an improved method for synthesizing [11C]phosgene using a carbon tetrachloride detection tube kit in environmental air analysis and the automated synthesis system for preparing [11C]phosgene have been developed in 2009. This apparatus has been used for routine synthesis of 11C-labeled tracers 1–4 times/week. Using [11C]phosgene we have developed and produced many PET radiotracers containing [11C]urea and [11C]carbamate moieties. In this review, we report the performance of our method for preparing [11C]phosgene, including automated synthesis apparatus developed in house, and the application of [11C]phosgene for development and production of 11C-labeled PET tracers.},
 pages = {138--148},
 title = {[11C]phosgene: Synthesis and application for development of PET radiotracers},
 volume = {92},
 year = {2021}
}