@article{oai:repo.qst.go.jp:00080126,
 author = {Oyama, Tomoko and Oyama, Kotaro and Taguchi, Mitsumasa and Oyama, Tomoko and Oyama, Kotaro and Taguchi, Mitsumasa},
 issue = {13},
 journal = {Lab on a Chip},
 month = {Jul},
 note = {Polydimethylsiloxane (PDMS) has many desirable features for microfluidics applications, but its hydrophobicity, the lack of a practical method for bonding PDMS layers, and unwanted deformation during use limit its use. We report a simple method for solving these problems simultaneously; by applying EB or γ-ray irradiation to stacked PDMS layers, we can not only bond the interfaces between the layers but also achieve long-lasting hydrophilization and sterilization of the internal microchannels and chambers, prevent nonspecific adsorption and absorption of hydrophobic small molecules, and enhance the mechanical strength of the material though crosslinking. This method is applicable in the mass production of 3D integrated PDMS microfluidic chips with some glass-like properties as well as for 3D structures with complex shapes that are difficult to fabricate with plastic or glass.},
 pages = {2354--2363},
 title = {A simple method for production of hydrophilic, rigid, and sterilized multi-layer 3D integrated polydimethylsiloxane microfluidic chips},
 volume = {20},
 year = {2020}
}