{"created":"2023-05-15T14:58:57.216022+00:00","id":79980,"links":{},"metadata":{"_buckets":{"deposit":"b7f1e864-b020-4090-b26c-5b9ae28d9239"},"_deposit":{"created_by":1,"id":"79980","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79980"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079980","sets":["11"]},"author_link":["868124","868123"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"13","bibliographicPageStart":"10","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Medical Science Digest"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"特定の脳内分子（標的分子）に結合する低分子化合物を放射性核種で標識し、プローブとして体内に投与することにより、ポジトロン断層撮影（positron emission tomography; PET）で標的分子の生体イメージングが可能になる。これにより、精神神経疾患病態における標的分子の変化が捉えられる。また、治療薬候補物質と標識プローブの標的分子への結合における競合を利用し、候補物質の標的分子への占有率を計測可能である。PETプローブは疾患モデル動物とヒトで共通して利用可能であり、プローブを利用した非臨床と臨床を双方向につなぐ研究開発を通じて、ヒトの病態解明や診断・治療法開発と、ヒトとの相動性検証に基づくモデル動物の妥当性評価が実現する。","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ニューサイエンス社"}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-4340","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"868123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"868124","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"実験動物を用いたプローブ開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"実験動物を用いたプローブ開発"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-25"},"publish_date":"2020-05-25","publish_status":"0","recid":"79980","relation_version_is_last":true,"title":["実験動物を用いたプローブ開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:55:17.540694+00:00"}