{"created":"2023-05-15T14:58:53.519095+00:00","id":79892,"links":{},"metadata":{"_buckets":{"deposit":"751fc076-afc7-4573-9d69-d6d8c09c2f42"},"_deposit":{"created_by":1,"id":"79892","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79892"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079892","sets":["1"]},"author_link":["866884","866883","866881","866882","866880"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"273","bibliographicPageStart":"263","bibliographicVolumeNumber":"193","bibliographic_titles":[{"bibliographic_title":"Radiation Research "}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, nanoparticles that release anticancer drugs upon irradiation were developed. Here, MM46 and MM48 tumors in C3He/N mice were irradiated. Furthermore, the intravenously (i.v.) injected nanoparticles were tested for\ntheir ability to deliver the anticancer drug, increase the antitumor effect via a synergistic effect of combining targeted anticancer drugs with radiation and decrease adverse effects by localizing the anticancer drug. The nanoparticles were prepared by spraying a mixture of hyaluronic acid and alginate, supplemented with carboplatin, into a solution of CaCl2 and FeCl2 through a 0.8-lm-pore stainless mesh filter. Nanoparticles (131010) were i.v. injected and irradiated (100-KeV soft X rays, 10–40 Gy) when the accumulation of\nparticles peaked. The nanoparticles were 547 6 43 nm in diameter. The i.v.-injected nanoparticles accumulated around tumors. Maximum accumulations were observed 9 h postinjection. Subsequently, 10–40 Gy of radiation was administered. The accumulated nanoparticles released the carboplatin\nand gelatinized their outer shells, which prolonged the intra-tumor concentration of carboplatin and increased the radiation-induced synergistic antitumor effect. The localization of carboplatin by nanoparticles significantly reduced the adverse effects of the anticancer drug.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Radiation Research Society"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1667/RR15357.1","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://bioone.org/journals/Radiation-Research/volume-193/issue-3/RR15357.1/Delivery-and-Effectiveness-of-Carboplatin-via-Targeted-Delivery-Compared-to/10.1667/RR15357.1.short","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"瀬川, 昂史(岩手医科大)"}],"nameIdentifiers":[{"nameIdentifier":"866880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田, 聡(岩手医科大)"}],"nameIdentifiers":[{"nameIdentifier":"866881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 隆博"}],"nameIdentifiers":[{"nameIdentifier":"866882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江原, 茂(岩手医科大)"}],"nameIdentifiers":[{"nameIdentifier":"866883","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"866884","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Delivery and Effectiveness of Carboplatin via Targeted Delivery Compared to Passive Accumulation of Intravenously Injected Particles Releasing Carboplatin upon Irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Delivery and Effectiveness of Carboplatin via Targeted Delivery Compared to Passive Accumulation of Intravenously Injected Particles Releasing Carboplatin upon Irradiation"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-15"},"publish_date":"2020-04-15","publish_status":"0","recid":"79892","relation_version_is_last":true,"title":["Delivery and Effectiveness of Carboplatin via Targeted Delivery Compared to Passive Accumulation of Intravenously Injected Particles Releasing Carboplatin upon Irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:57:08.250151+00:00"}