@article{oai:repo.qst.go.jp:00079892,
 author = {瀬川, 昂史(岩手医科大) and 原田, 聡(岩手医科大) and 佐藤, 隆博 and 江原, 茂(岩手医科大) and Sato, Takahiro},
 issue = {3},
 journal = {Radiation Research},
 month = {Apr},
 note = {In this study, nanoparticles that release anticancer drugs upon irradiation were developed. Here, MM46 and MM48 tumors in C3He/N mice were irradiated. Furthermore, the intravenously (i.v.) injected nanoparticles were tested for
their ability to deliver the anticancer drug, increase the antitumor effect via a synergistic effect of combining targeted anticancer drugs with radiation and decrease adverse effects by localizing the anticancer drug. The nanoparticles were prepared by spraying a mixture of hyaluronic acid and alginate, supplemented with carboplatin, into a solution of CaCl2 and FeCl2 through a 0.8-lm-pore stainless mesh filter. Nanoparticles (131010) were i.v. injected and irradiated (100-KeV soft X rays, 10–40 Gy) when the accumulation of
particles peaked. The nanoparticles were 547 6 43 nm in diameter. The i.v.-injected nanoparticles accumulated around tumors. Maximum accumulations were observed 9 h postinjection. Subsequently, 10–40 Gy of radiation was administered. The accumulated nanoparticles released the carboplatin
and gelatinized their outer shells, which prolonged the intra-tumor concentration of carboplatin and increased the radiation-induced synergistic antitumor effect. The localization of carboplatin by nanoparticles significantly reduced the adverse effects of the anticancer drug.},
 pages = {263--273},
 title = {Delivery and Effectiveness of Carboplatin via Targeted Delivery Compared to Passive Accumulation of Intravenously Injected Particles Releasing Carboplatin upon Irradiation},
 volume = {193},
 year = {2020}
}