{"created":"2023-05-15T14:58:50.586168+00:00","id":79824,"links":{},"metadata":{"_buckets":{"deposit":"56f7ca65-2c18-464d-bfdf-50d4a0a56d82"},"_deposit":{"created_by":1,"id":"79824","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79824"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079824","sets":["1"]},"author_link":["866778","866775","866777","866774","866776"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"809","bibliographicPageStart":"801","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"International journal of clinical oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Significant technological advances in radiotherapy have been made in the past few decades. High-precision radiotherapy has recently become popular and is contributing to improvements in the local control of the irradiated target lesions and the reduction of adverse effects. Accordingly, for long-term survival, the importance of systemic cancer control, including at non-irradiated sites, is growing. Toward this challenge, the treatment methods in which anti-PD-1/PD-L1 antibodies that exert systemic effects by restoring anti-tumour immunity are combined with radiotherapy has attracted attention in recent years. Previous studies have reported the activation of anti-tumour immunity by radiotherapy, which simultaneously elevates PD-L1 expression, suggesting a potential for combination therapy. Radiotherapy induces so-called 'immunogenic cell death', which involves cell surface translocation of calreticulin and extracellular release of high-mobility group protein box 1 (HMGB-1) and adenosine-5'-triphosphate (ATP). Furthermore, radiotherapy causes immune activation via MHC class I upregulation and cGAS-STING pathway. In contrast, induction of immunosuppressive lymphocytes and the release of immunosuppressive cytokines and chemokines by radiotherapy contribute to immunosuppressive reactions. In this article, we review immune responses induced by radiotherapy as well as previous reports to support the rationale of combination of radiotherapy and anti-PD-1/PD-L1 antibodies. A number of preclinical and clinical studies have shown the efficacy of radiotherapy combined with immune checkpoint inhibition, hence combination therapy is considered to be an important future strategy for cancer treatment.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer-Verlag Tokyo"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32246277","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10147-020-01666-1","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://link.springer.com/article/10.1007%2Fs10147-020-01666-1","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-9625","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Hiro"}],"nameIdentifiers":[{"nameIdentifier":"866774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okonogi, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"866775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"866776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okonogi, Noriyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"866777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"866778","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-08"},"publish_date":"2020-04-08","publish_status":"0","recid":"79824","relation_version_is_last":true,"title":["Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:57:19.233678+00:00"}