{"created":"2023-05-15T14:58:44.109844+00:00","id":79682,"links":{},"metadata":{"_buckets":{"deposit":"f6f199dc-302b-4a0e-afec-8f5e4881bac4"},"_deposit":{"created_by":1,"id":"79682","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79682"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079682","sets":["11"]},"author_link":["860257","860258","860261","860256","860259","860260"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Drug Delivery System"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"α線はβ線に比べ狭い範囲に高いエネルギーを付与することができるため，細胞殺傷力が高い。そのα線を放出する核種で抗体を標識した治療法をα線放射免疫療法(α-RIT)と呼ぶ。α-RITの高いポテンシャルは認識されていたものの，これまで実施された臨床試験は血液腫瘍では多いが，固形がんでは多くはなかった。しかし，2017年から，今後の固形がんを対象にしたα-RITの主役を担うと考えられる225Acと227Thを使用した臨床試験が相次いで開始されるなど，α-RITの開発研究が精力的に進められるようになってきている。本稿では，放射免疫療法の基礎，α-RITの現状及び課題を紹介する。","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"860256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤, 仁美"}],"nameIdentifiers":[{"nameIdentifier":"860257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭, 綾"}],"nameIdentifiers":[{"nameIdentifier":"860258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"860259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sudo, Hitomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"860260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugyo, Aya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"860261","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"α線放射免疫療法開発研究の現状と課題","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"α線放射免疫療法開発研究の現状と課題"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-26"},"publish_date":"2020-03-26","publish_status":"0","recid":"79682","relation_version_is_last":true,"title":["α線放射免疫療法開発研究の現状と課題"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:11:18.497739+00:00"}